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TAKEDA PHARMACEUTICAL COMPANY LIMITED

(4502)
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Takeda Pharmaceutical : Summary of Financial Statements for the Three-month Period Ended June 30, 2021 (IFRS, Consolidated) (Form 6-K)

07/30/2021 | 08:10am EDT
Summary of Financial Statements for the Three-month Period Ended June 30, 2021 (IFRS, Consolidated)
July 30, 2021
Takeda Pharmaceutical Company Limited Stock exchange listings: Tokyo, Nagoya, Fukuoka, Sapporo
TSE Code: 4502
Representative: Christophe Weber, President & CEO
Contact: Christopher O'Reilly Telephone: +81-3-3278-2306
Email: takeda.ir.contact@takeda.com
Global Head of IR, Global Finance
Scheduled date of securities report submission: August 6, 2021
Scheduled date of dividend payment commencement: -
Supplementary materials for the financial statements: Yes
Presentation to explain for the financial statements: Yes
(Million JPY, rounded to the nearest million)
1.
Consolidated Financial Results for the Three-month Period Ended June 30, 2021 (April 1 to June 30, 2021)
(1)Consolidated Operating Results (year to date)
(Percentage figures represent changes over the same period of the previous year)
Revenue Operating profit Profit before tax Net profit
for the period
(Million JPY) (%) (Million JPY) (%) (Million JPY) (%) (Million JPY) (%)
Three-month Period Ended June 30, 2021 949,603 18.4 248,552 48.6 222,978 71.1 200,421 142.9
Three-month Period Ended June 30, 2020 801,850 (5.6) 167,285 270.4 130,291 - 82,519 -
Net profit attributable to
owners of the Company
Total comprehensive
income for the period
Basic earnings
per share
Diluted earnings
per share
(Million JPY) (%) (Million JPY) (%) (JPY) (JPY)
Three-month Period Ended June 30, 2021 200,378 142.8 258,521 165.8 128.02 127.27
Three-month Period Ended June 30, 2020 82,511 - 97,258 - 52.93 52.69
Core Operating Profit Core EPS
(Billion JPY) (%) (JPY)
Three-month Period Ended June 30, 2021 248.9 (11.4) 113
Three-month Period Ended June 30, 2020 280.9 (0.7) 122

(2)Consolidated Financial Position
Total assets
(Million JPY)
Total equity
(Million JPY)
Equity attributable
to owners of the
Company
(Million JPY)
Ratio of equity
attributable to
owners of the
Company to total
assets (%)
Equity attributable
to owners of the
Company per
share (JPY)
As of June 30, 2021
12,657,234 5,300,159 5,299,774 41.9 3,378.55
As of March 31, 2021
12,912,293 5,177,177 5,173,037 40.1 3,308.93



2. Dividends
Annual dividends per share (JPY)
1st quarter end 2nd quarter end 3rd quarter end Year-end Total
For the Fiscal Year Ended March 31, 2021
- 90.00 - 90.00 180.00
For the Fiscal Year Ending March 31, 2022
-
For the Fiscal Year Ending March 31, 2022 (Projection)
90.00 - 90.00 180.00
(Note) Modifications in the dividend projection from the latest announcement: None

3.
Forecasts for Consolidated Operating Results for the Fiscal Year Ending March 31, 2022 (April 1, 2021 to March 31, 2022)
(Percentage figures represent changes from previous fiscal year)
Revenue Core Operating Profit Operating profit Profit before
income taxes
Net profit attributable to owners of the Company Basic
earnings
per share
Core EPS
(Million JPY) (%) (Million JPY) (%) (Million JPY) (%) (Million JPY) (%) (Million JPY) (%) (JPY) (JPY)
For the Fiscal Year Ending March 31, 2022
3,370,000 5.4 930,000 (3.9) 488,000 (4.2) 352,000 (3.9) 250,000 (33.5) 159.91 394
(Note) Modifications in forecasts of consolidated operating results from the latest announcement: None
FY2021 Management Guidance
Underlying Revenue Growth Mid-single-digit growth
Underlying Core Operating Profit Growth Mid-single-digit growth
Underlying Core Operating Profit Margin ~30% margin
Underlying Core EPS Growth Mid-single-digit growth
(Note) Please refer to page 6 for details of 'Underlying growth'.



▪Additional Information
(1) Changes in significant subsidiaries during the period : No
(changes in specified subsidiaries resulting in the change in consolidation scope)
(2) Changes in accounting policies and changes in accounting estimates
1) Changes in accounting policies required by IFRS : No
2) Changes in accounting policies other than 1) : No
3) Changes in accounting estimates : No
(3) Number of shares outstanding (common stock)
1) Number of shares outstanding (including treasury stock) at period end:
June 30, 2021 1,578,378,220 shares
March 31, 2021 1,576,387,908 shares
2) Number of shares of treasury stock at period end:
June 30, 2021 9,723,017 shares
March 31, 2021 13,029,749 shares
3) Average number of outstanding shares (for the three-month period ended June 30):
June 30, 2021 1,565,249,233 shares
June 30, 2020 1,558,969,468 shares
▪This summary of quarterly financial statements is not subject to quarterly review by the external auditor
▪Note to ensure appropriate use of forecasts, and other noteworthy items
Takeda applies International Financial Reporting Standards (IFRS), and the disclosure information in this document is based on IFRS.
All forecasts in this document are based on information currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. Should any significant event occur which requires the forecast to be revised, Takeda will disclose it in a timely manner.
For details of the financial forecast, please refer to '1. Financial Highlights for the Three-month Period Ended June 30, 2021 (3) Outlook for the Fiscal Year Ending March 31, 2022' on page 10.
Supplementary materials for the financial statements including the Quarterly Financial Report and Earnings Presentation of the conference call on July 30, 2021, and its video will be promptly posted on Takeda's website.

(Takeda Website):


Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
Attachment Index
2
2
8
10
12
14
14
15
16
18
20
22

1
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
1. Financial Highlights for the Three-month Period Ended June 30, 2021
(1) Business Performance
(i) Consolidated Financial Results (April 1 to June 30, 2021)
Billion JPY or percentage
FY2020Q1 FY2021Q1 Change versus the same period of the previous fiscal year
Revenue 801.9 949.6 147.8 18.4 %
Cost of sales (238.1) (241.3) (3.2) 1.3 %
Selling, general and administrative expenses (202.4) (219.8) (17.5) 8.6 %
Research and development expenses (106.8) (122.5) (15.7) 14.7 %
Amortization and impairment losses on intangible assets associated with products (104.2) (102.8) 1.4 (1.4) %
Other operating income 63.7 11.1 (52.6) (82.6) %
Other operating expenses (46.8) (25.8) 21.0 (44.9) %
Operating profit 167.3 248.6 81.3 48.6 %
Finance income and (expenses), net (27.2) (25.2) 2.0 (7.4) %
Share of loss of investments accounted for using the equity method (9.8) (0.4) 9.4 (96.3) %
Profit before tax 130.3 223.0 92.7 71.1 %
Income tax expenses (47.8) (22.6) 25.2 (52.8) %
Net profit for the period 82.5 200.4 117.9 142.9 %
Revenue. Revenue for the three-month period ended June 30, 2021 was 949.6 billion JPY, an increase of 147.8 billion JPY, or 18.4%, compared to the same period of the previous fiscal year. Excluding the impact from fluctuations in foreign exchange rates, which was calculated by translating revenue of the three-month period ended June 30, 2021 using corresponding exchange rates in the same period of the previous fiscal year, the increase in revenue was 14.3%. In April 2021, Takeda completed the sale of a portfolio of diabetes products in Japan to Teijin Pharma Limited for 133.0 billion JPY, which was recorded as revenue and accounted for 16.6 percentage points ('pp') of the increase in revenue. Excluding this selling price from revenue for the three-month period ended June 30, 2021, the increase was 1.8%.
Each of our core therapeutic areas (i.e. Gastroenterology ('GI'), Rare Diseases, Plasma-Derived Therapies ('PDT') Immunology, Oncology, and Neuroscience) contributed to positive revenue growth; however, Rare Diseases and PDT Immunology would have declined if not for the positive impact of the depreciation of the yen. Intensified competition, generic erosion, and shipment timing impacted some products in these two areas. Overall, the global spread of COVID-19 did not have a material effect on our revenue for the three-month period ended June 30, 2021.
Revenue outside of our core therapeutic areas increased by 101.8 billion JPY, or 72.8%, compared to the same period of the previous fiscal year to 241.6 billion JPY, largely due to the 133.0 billion JPY selling price of the diabetes portfolio in Japan, offsetting the impact from divestitures.
Year-on-year change in revenue for this three-month period in each of our main therapeutic areas was primarily attributable to the following products:
•GI. In Gastroenterology, revenue was 210.5 billion JPY, a year-on-year increase of 23.6 billion JPY, or 12.6%. Growth was driven by Takeda's top-selling product ENTYVIO (for ulcerative colitis ('UC') and Crohn's disease ('CD')), with sales of 125.4 billion JPY, a year-on-year increase of 24.1 billion JPY, or 23.9%. Sales in the U.S. increased by 12.2 billion JPY, or 17.1%, to 83.7 billion JPY and sales in Europe and Canada increased by 8.6 billion JPY, or 35.6%, to 32.7 billion JPY, due to an increase in demand. In the Growth and Emerging Markets, the increase in sales was primarily driven by Brazil and China. Sales of TAKECAB (for acid-related diseases) were 24.3 billion JPY, an increase of 4.1 billion JPY, or 20.1%, versus the same period of the previous fiscal year. This increase was driven by the expansion of new prescriptions in the Japanese market due to TAKECAB's efficacy in reflux esophagitis and the prevention of recurrence of gastric and duodenal ulcers during low-dose aspirin administration. Sales of AMITIZA (for chronic constipation) decreased by 4.1 billion JPY, or 65.8%, to 2.1 billion JPY, due to generic entrants in the U.S. in January 2021.
•Rare Diseases. In Rare Diseases, revenue was 155.5 billion JPY, a slight year-on-year increase of 0.5 billion JPY, or 0.3%.
Revenue in Rare Metabolic increased by 4.3 billion JPY, or 10.9%, compared to the same period of the previous fiscal year to 44.3 billion JPY. Sales of enzyme replacement therapies REPLAGAL (for Fabry disease), VPRIV (for Gaucher disease)
2
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
and ELAPRASE (for Hunter syndrome) increased due to higher demand coupled with the positive impact of the depreciation of the yen.
Revenue in Rare Hematology decreased by 4.6 billion JPY, or 5.9%, to 72.2 billion JPY. Sales of ADVATE decreased by 3.0 billion JPY, or 8.9%, to 30.7 billion JPY. Sales of ADYNOVATE increased by 0.1 billion JPY, or 0.6%, to 15.4 billion JPY, helped by the positive impact of the depreciation of the yen. Both products were impacted by the competitive landscape in the hemophilia A non-inhibitors market in the U.S. FEIBA sales decreased by 1.5 billion JPY, or 11.3%, to 11.4 billion JPY.
Revenue in Hereditary Angioedema ('HAE') was 39.0 billion JPY, a year-on-year increase of 0.7 billion JPY, or 1.8%. Sales of TAKHZYRO were 25.5 billion JPY, an increase of 2.2 billion JPY, or 9.6%, versus the same period of the previous fiscal year primarily due to new launches including prefilled syringe administration in Europe. Sales of FIRAZYR decreased by 1.2 billion JPY, or 15.1%, to 6.9 billion JPY, primarily due to the continued impact of generic entrants in the U.S.
•PDT Immunology. In Plasma-Derived Therapies ('PDT') Immunology, revenue increased by 1.9 billion JPY, or 1.8%, compared to the same period of the previous fiscal year to 107.2 billion JPY. Aggregate sales of immunoglobulin products were 81.6 billion JPY, a decrease of 3.5 billion JPY, or 4.1%, compared to the same period of the previous fiscal year. In particular, GAMMAGARD LIQUID (for the treatment of primary immunodeficiency ('PID') and multifocal motor neuropathy ('MMN')) decreased in sales mainly due to shipment timing, as the last three-month period of the previous fiscal year saw higher sales. On the other hand, CUVITRU, a SCIG (subcutaneous immunoglobulin) therapy continued to mark double digit growth. Aggregate sales of albumin products including HUMAN ALBUMIN and FLEXBUMIN (primarily used for hypovolemia and hypoalbuminemia) were 17.8 billion JPY, an increase of 4.8 billion JPY, or 36.8%, versus the same period of the previous fiscal year driven by the resolution of the temporary supply interruption impacting HUMAN ALBUMIN for release in China which impacted the second half of the previous fiscal year.
•Oncology. In Oncology, revenue was 121.4 billion JPY, a year-on-year increase of 13.4 billion JPY, or 12.4%. Sales of VELCADE (for multiple myeloma) increased by 5.9 billion JPY, or 24.6% versus the same period of the previous fiscal year to 30.1 billion JPY. While royalty income outside the U.S. decreased by 0.3 billion JPY, or 30.8%, due to continued generic erosion, sales in the U.S. increased by 6.3 billion JPY, or 27.3%, versus the same period of the previous fiscal year, reflecting a rebound in demand after lower sales in the same period of the prior year when prescribers favored orally administered products over infusions or injections, as a result of the COVID-19 outbreak. Sales of NINLARO (for multiple myeloma) were 24.4 billion JPY, an increase of 1.4 billion JPY, or 6.3%, versus the same period of the previous fiscal year. NINLARO's convenient profile as an orally administered treatment led to a temporary increase in demand in light of the spread of COVID-19, especially in the first few months of the previous fiscal year, because its administration reduced some of the logistical burden for patients visiting a hospital, clinic or physician's office to get an infusion or injection. This benefit has since normalized in the U.S.; however, there have been strong demand increases in other countries, particularly in China. Sales of ADCETRIS (for malignant lymphomas) increased by 2.1 billion JPY, or 14.2% versus the same period of the previous fiscal year to 17.2 billion JPY, led by strong growth in sales in the Growth and Emerging Markets, particularly in China where it was approved in May 2020. Sales of LEUPLIN/ENANTONE (generic name: leuprorelin) (for endometriosis, uterine fibroids, premenopausal breast cancer, prostatic cancer, etc.), an off-patented product, decreased by 1.2 billion JPY, or 4.3%, versus the same period of the previous fiscal year to 26.2 billion JPY mainly due to generic erosion and competition in Japan.
•Neuroscience. In Neuroscience, revenue was 113.4 billion JPY, a year-on-year increase of 6.6 billion JPY, or 6.1%. Sales of VYVANSE/ELVANSE (for attention deficit hyperactivity disorder ('ADHD')) were 79.2 billion JPY, an increase of 13.2 billion JPY, or 20.0%, versus the same period of the previous fiscal year. VYVANSE/ELVANSE has been negatively affected by COVID-19 during the course of the pandemic, most notably during periods when stay-at-home restrictions have been in place reducing patient visits, subsequent diagnoses and creating temporary discontinuation of medication. The trend has been fluctuating throughout 2020 and into 2021; however, when comparing the three-month period of the current fiscal year with the same period of the previous fiscal year, there has been a positive impact from increasing prescriptions. Sales of TRINTELLIX (for major depressive disorder ('MDD')) were 17.9 billion JPY, an increase of 1.0 billion JPY, or 5.9%, versus the same period of the previous fiscal year, primarily due increasing market penetration in Japan. The increase of these products was partially offset by the decrease of other neuroscience products such as REMINYL (for Alzheimer's disease) and ADDERALL XR (for ADHD), attributable to the continued impact of competition from generic products.
3
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
Revenue by Geographic Region:
Billion JPY; percentages are portion of total revenue
Revenue: FY2020Q1 FY2021Q1
Japan*1
144.0 18.0 % 259.0 27.3 %
United States 402.6 50.2 % 412.2 43.4 %
Europe and Canada 157.6 19.6 % 178.7 18.8 %
Asia (excluding Japan) 36.9 4.6 % 40.3 4.2 %
Latin America 30.8 3.8 % 30.1 3.2 %
Russia/CIS 13.0 1.6 % 12.3 1.3 %
Other*2
16.9 2.1 % 17.0 1.8 %
Total 801.9 100.0 % 949.6 100.0 %
*1 The 133.0 billion JPY selling price of the sale of diabetes portfolio in Japan is included in the three-month period ended June 30, 2021.
*2 Other includes the Middle East, Oceania and Africa.

Cost of Sales. Cost of Sales increased by 3.2 billion JPY, or 1.3%, to 241.3 billion JPY and the Cost of Sales Ratio decreased by 4.3pp compared to the same period of the previous fiscal year to 25.4%. The increase was primarily due to the depreciation of the yen during the current period as compared to same period of the previous fiscal year, however, this increase was partially offset by a 15.4 billion JPY decrease in non-cash charges related to the unwind of the fair value step up on acquired inventory recognized in connection with the acquisition of Shire plc (the 'Shire Acquisition'). The main reason for the decrease in the Cost of Sales Ratio was the effect of the sale of a portfolio of diabetes products in Japan with the selling price of 133.0 billion JPY being recorded in revenue.

Selling, General and Administrative (SG&A) expenses. SG&A expenses increased by 17.5 billion JPY, or 8.6%, to 219.8 billion JPY compared to the same period of the previous fiscal year, mainly due to the impact from the depreciation of the yen in the current period.

Research and Development (R&D) expenses. R&D expenses increased by 15.7 billion JPY, or 14.7%, to 122.5 billion JPY compared to the same period of the previous fiscal year, mainly due to further investment in prioritized new molecular entities as well as the impact from the depreciation of the yen in the current period.
Amortization and Impairment Losses on Intangible Assets Associated with Products. Amortization and Impairment Losses on Intangible Assets Associated with Products decreased by 1.4 billion JPY, or 1.4%, to 102.8 billion JPY compared to the same period of the previous fiscal year.
Other Operating Income. Other Operating Income was 11.1 billion JPY, a decrease of 52.6 billion JPY, or 82.6%, compared to the same period of the previous fiscal year, mainly driven by a 60.2 billion JPY revaluation gain recorded in the same period of the previous fiscal year triggered by an update to previously recognized liabilities for pipeline compound SHP647 and certain associated rights ('SHP647'), to reflect management's decision to terminate the clinical trial program following the European Commission's decision in May 2020 to release Takeda's obligation to divest SHP647.
Other Operating Expenses. Other Operating Expenses were 25.8 billion JPY, a decrease of 21.0 billion JPY, or 44.9%, compared to the same period of the previous fiscal year. This is mainly attributable to a 18.6 billion JPY loss recognized in the same period of the previous year from changes in the fair value of contingent consideration assets from the divestment of XIIDRA. There was also a 8.1 billion JPY decrease in restructuring expenses mainly attributable to lower Shire integration costs. A negative impact of the valuation reserve for pre-launch inventories by 4.5 billion JPY partially offset this decrease.
Operating Profit. As a result of the above factors, Operating Profit increased by 81.3 billion JPY, or 48.6% compared to the same period of the previous fiscal year to 248.6 billion JPY.

Net Finance Expenses. Net Finance Expenses were 25.2 billion JPY in the current period, a decrease of 2.0 billion JPY compared to the same period of the previous fiscal year. The decrease is mainly due to a gain on prior equity method investments related to the acquisition of Maverick Therapeutics, Inc. in April 2021, partially offset by the negative impact from remeasurement of the warrant to purchase stocks of a company held by Takeda.

4
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
Share of Loss of Investments Accounted for Using the Equity Method.Share of Loss of Investments Accounted for Using the Equity Methodwas 0.4 billion JPY, a decrease of 9.4 billion JPY compared to the same period of the previous fiscal year. This was mainly due to Takeda's shareholding ratio of impairment loss recognized by Teva Takeda Pharma Ltd. for the same period of the previous fiscal year resulting from the reassessment of the recoverable amount of relevant assets triggered by the decision to divest a part of its generics business and a manufacturing plant.

Income Tax Expenses. Income Tax Expenses were 22.6 billion JPY, a decrease of 25.2 billion JPY compared to the same period of the previous year. This decrease was primarily due to the tax benefits from internal entity restructuring transactions in the current period and a decrease in unitary tax on overseas subsidiaries in the current period versus the same period of the previous year. These decreases were partially offset by higher pretax earnings in the current period.
Net Profit for the Period. Net Profit for the Period increased by 117.9 billion JPY, compared to the same period of the previous fiscal year to 200.4 billion JPY.
5
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(ii) Underlying Results (April 1 to June 30, 2021)
Definition of Core and Underlying Growth
Takeda uses the concept of Underlying Growth for internal planning and performance evaluation purposes.

Underlying Growth compares two periods (fiscal quarters or years) of financial results under a common basis and is used by management to assess the business. These financial results are calculated on a constant currency basis using a full year plan rate and exclude the impacts of divestitures and other amounts that are unusual, non-recurring items or unrelated to our ongoing operations. Although these are not measures defined by IFRS, Takeda believes Underlying Growth is useful to investors as it provides a consistent measure of our performance.

Takeda uses 'Underlying Revenue Growth', 'Underlying Core Operating Profit Growth', and 'Underlying Core EPS Growth' as key financial metrics.

Underlying Revenue represents revenue on a constant currency basis and excluding non-recurring items and the impact of divestitures that occurred during the reported periods presented.

Underlying Core Operating Profit represents Core Operating Profit (as defined below) on a constant currency basis and further adjusted to exclude the impacts of divestitures that occurred during the reporting periods presented.

Underlying Core EPS represents net profit based on a constant currency basis, adjusted to exclude the impact of divestitures, items excluded in the calculation of Core EPS (as defined below), divided by the outstanding shares (excluding treasury shares) as of the end of the comparative period.

Core Revenue represents revenue adjusted to exclude significant items unrelated to Takeda's core operations.

Core Operating Profit represents net profit adjusted to exclude income tax expenses, the share of profit or loss of investments accounted for using the equity method, finance expenses and income, other operating expenses and income, amortization and impairment losses on acquired intangible assets and other items unrelated to Takeda's core operations, such as non-recurring items, purchase accounting effects and transaction related costs.

Core EPS represents net profit adjusted to exclude the impact of items excluded in the calculation of Core Operating Profit, and other non-operating items (e.g. amongst other items, fair value adjustments and the imputed financial charge related to contingent consideration) that are unusual, non-recurring in nature or unrelated to Takeda's ongoing operations and the tax effect of each of the adjustments, divided by the average outstanding shares (excluding treasury shares) of the reporting periods presented.

Underlying Results
FY2021Q1
Underlying Revenue Growth +3.8%
Underlying Core Operating Profit Growth -2.1%
Underlying Core Operating Profit Margin 30.5%
Underlying Core EPS Growth +3.9%

Underlying Revenue Growth was 3.8% compared to the same three-month period of the previous fiscal year. Underlying revenue attributable to Takeda's 14 global brands* grew by 6.8%, despite a decline of GAMMAGARD LIQUID/KIOVIG.
*Takeda's 14 global brands
GI: ENTYVIO, GATTEX/REVESTIVE, ALOFISEL
Rare Diseases: NATPARA/NATPAR, ADYNOVATE/ADYNOVI, TAKHZYRO, ELAPRASE, VPRIV
PDT Immunology: GAMMAGARD LIQUID/KIOVIG, HYQVIA, CUVITRU, HUMAN ALUBUMIN/FLEXBUMIN
Oncology: NINLARO, ALUNBRIG
6
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
Underlying Revenue Growth by Therapeutic Area
GI +7.9%
Rare Diseases -3.4%
Rare Metabolic +6.6%
Rare Hematology -9.4%
Hereditary Angioedema -1.7%
PDT Immunology -1.8%
Oncology +8.9%
Neuroscience +2.9%
Other +9.0%
Total +3.8%
(Note) Underlying Revenue represents revenue on a constant currency basis and excluding non-recurring items and the impact of divestitures. Please refer to 1. Financial Highlights for the Three-month Period Ended June 30, 2021, (1) Business Performance, (i) Consolidated Financial Results, for the revenue of each core therapeutic areas and sales of major products before underlying adjustments.

The impact of major non-recurring items and divestitures excluded to calculate Underlying Revenue:
•Revenue of select over-the-counter and non-core products in Asia Pacific is excluded from the same period of the previous fiscal year as the divestiture was completed in November 2020.
•Revenue of select non-core prescription pharmaceutical products predominantly in Europe is excluded from the same period of the previous fiscal year as the divestiture was completed in December 2020.
•Revenue of select over-the-counter and non-core products in Latin America is excluded from the same period of the previous fiscal year as the divestiture was completed in January 2021.
•Net sales from TACHOSIL, a surgical patch, are excluded from the same period of the previous fiscal year as the divestiture was completed in January 2021.
•Revenue of select over-the-counter and non-core products predominantly in Europe is excluded from the same period of the previous fiscal year as the divestiture was completed in March 2021.
•Revenue of the former subsidiary, Takeda Consumer Healthcare Company Limited is excluded from the same period of the previous fiscal year as the divestiture was completed in March 2021.
•Net sales from a portfolio of diabetes products in Japan (NESINA, LIOVEL, INISYNC and ZAFATEK) are excluded from the same period of the previous fiscal year as the divestiture was completed at the beginning of April 2021. In addition, the non-recurring item of the 133.0 billion JPY selling price as the result of the completion of the divestiture is excluded from the current period.
•Revenue of select non-core prescription pharmaceutical products in China is excluded from both the current period and the same period of the previous fiscal year as the divestiture was publicly announced and had been expected to complete within the first half of the current fiscal year.

Underlying Core Operating Profit Growth was -2.1% over the same three-month period of the previous fiscal year, reflecting increase in R&D investment.

Core Operating Profit for the current period, which excludes items unrelated to Takeda's core operations such as the sale of a portfolio of diabetes products in Japan, was 248.9 billion JPY.

Underlying Core Operating Profit Margin for the current period was 30.5%.

Underlying Core EPS Growth for the current period was 3.9%.

7
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(2) Consolidated Financial Position
Assets. Total Assets as of June 30, 2021 were 12,657.2 billion JPY, reflecting a decrease of 255.1 billion JPY compared to the previous fiscal year-end. Cash and Cash Equivalents decreased by 311.3 billion JPY, and Intangible Assets decreased by 52.7 billion JPY mainly due to amortization. These decreases were partially offset by an increase in Trade and Other Receivables of 44.2 billion JPY and an increase in Inventories of 25.3 billion JPY.
Liabilities. Total Liabilities as of June 30, 2021 were 7,357.1 billion JPY, reflecting a decrease of 378.0 billion JPY compared to the previous fiscal year-end. Bonds and Loans decreased by 229.5 billion JPY to 4,405.9 billion JPY* primarily as a result of the repayment of loans and the redemption of bonds. In addition, Provisions decreased by 63.8 billion JPY.
* The carrying amount of Bonds was 3,524.0 billion JPY and Loans was 881.9 billion JPY as of June 30, 2021. Breakdown of Bonds and Loans carrying amount is as follows.
Bonds:
Name of Bond
(Face Value if Denominated in
Foreign Currency)
Issuance Maturity Carrying Amount
(Billion JPY)
Unsecured US dollar denominated senior notes (1,520 million USD) June 2015 June 2022 ~
June 2045
167.9
Unsecured US dollar denominated senior notes (5,500 million USD) September 2016 September 2023 ~
September 2026
578.8
Unsecured Euro denominated senior notes (5,250 million EUR) November 2018 November 2022 ~
November 2030
685.8
Unsecured US dollar denominated senior notes (3,250 million USD) November 2018 November 2023 ~
November 2028
357.1
Hybrid bonds (subordinated bonds) June 2019 June 2079 497.6
Unsecured US dollar denominated senior notes (7,000 million USD) July 2020 March 2030 ~
July 2060
767.7
Unsecured Euro denominated senior notes (3,600 million EUR) July 2020 July 2027 ~
July 2040
469.1
Total 3,524.0
Loans:
Name of Loan
(Face Value if Denominated in
Foreign Currency)
Execution Maturity Carrying Amount
(Billion JPY)
Syndicated loans April 2016 April 2023 ~
April 2026
200.0
Syndicated loans April 2017 April 2027 113.5
Syndicated loans
(1,500 million USD)
April 2017 April 2027 165.4
Japan Bank for International Cooperation
(1,700 million USD)
January 2019 December 2025 187.8
Bilateral loans March 2016 ~
April 2017
March 2023 ~
March 2026
210.0
Other 5.1
Total 881.9
On May 17, 2021, Takeda redeemed the remaining 200 million USD of unsecured U.S. dollar-denominated senior notes issued in July 2017 in advance of their original maturity date of January 18, 2022. Following this, on June 11, 2021, Takeda prepaid 2,000 million USD of the Japan Bank for International Cooperation loan amount of 3,700 million USD (that was entered into on December 3, 2018) in advance of its original maturity date of December 11, 2025.
8
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
Equity. Total Equity as of June 30, 2021 was 5,300.2 billion JPY, an increase of 123.0 billion JPY compared to the previous fiscal year-end. This was mainly due to a 57.9 billion JPY increase in Other Components of Equity primarily as a result of fluctuation in currency translation adjustments reflecting the depreciation of the yen as well as an increase of 56.6 billion JPY in Retained Earnings resulting from Net Profit for the Period partially offset by dividends payment of 141.9 billion JPY.
Consolidated Cash Flow
Billion JPY
FY2020Q1 FY2021Q1
Net cash from (used in) operating activities 145.9 166.9
Net cash from (used in) investing activities 0.7 (70.4)
Net cash from (used in) financing activities (192.8) (411.0)
Net increase (decrease) in cash and cash equivalents (46.2) (314.6)
Cash and cash equivalents at the beginning of the year 637.6 966.2
Effects of exchange rate changes on cash and cash equivalents (1.6) 3.3
Cash and cash equivalents at the end of the period 589.8 654.9
Net cash from operating activities was 166.9 billion JPY for the current period compared to 145.9 billion JPY for the same period of the previous year. The increase of 21.0 billion JPY was driven by higher net profit for the period adjusted for non-cash items and other adjustments, including the income relating to the release from the obligation to divest the pipeline compound SHP 647 and certain associated rights in the same period of the previous year. It was partially offset by a decrease in provisions and an increase in inventories.
Net cash used in investing activities was 70.4 billion JPY for the current period compared to the net cash from investing activities of 0.7 billion JPY for the same period of the previous year. This increase in net cash used of 71.1 billion JPY was mainly due to a decrease of 44.0 billion JPY in proceeds from sales and redemption of investments and an increase of 27.5 billion JPY in acquisition of business, net of cash and cash equivalents acquired.
Net cash used in financing activities was 411.0 billion JPY for the current period compared to 192.8 billion JPY for the same period of the previous year. This increase in net cash used of 218.3 billion JPY was mainly due to an increase in repayments of bonds and long-term loans of 232.9 billion JPY partially offset by the favorable impact from short-term loans and commercial papers of 10.0 billion JPY.
9
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(3) Outlook for the Fiscal Year Ending March 31, 2022
The full year consolidated reported forecast for the fiscal year ending March 31, 2022 (FY2021) has not been changed from the original forecast (announced at the FY2020 financial results announcement on May 11, 2021).
Full Year Reported Forecast for the Fiscal Year Ending March 31, 2022 (FY2021)
Billion JPY or percentage
FY2020 FY2021 Change over the previous year
Revenue 3,197.8 3,370.0 +172.2 +5.4 %
Operating profit 509.3 488.0 (21.3) (4.2) %
Profit before tax 366.2 352.0 (14.2) (3.9) %
Net profit for the year
(attributable to owners of the Company)
376.0 250.0 (126.0) (33.5) %
EPS (JPY) 240.72 159.91 (80.81) (33.6) %
Core Operating Profit 967.9 930.0 (37.9) (3.9) %
Core EPS (JPY) 420 394 (26) (6.2) %

Major assumptions used in preparing the FY2021 Reported Forecast
Billion JPY or percentage
FY2020 FY2021
FX rates 1 USD = 106 JPY
1 Euro = 123 JPY
1 RUB = 1.4 JPY
1 BRL = 19.6 JPY
1 CNY = 15.5 JPY
1 USD = 108 JPY
1 Euro = 131 JPY
1 RUB = 1.4 JPY
1 BRL = 19.9 JPY
1 CNY = 16.8 JPY
R&D expenses (455.8) (522.0)
Amortization of intangible assets associated with products (405.3) (406.0)
Of which Shire acquisition related (319.5) (328.0)
Impairment of intangible assets associated with products (16.6) (50.0)
Other operating income 318.0 23.0
Other operating expenses (258.9) (100.0)
Japan diabetes portfolio divestiture gain - 130.0
Other Core Operating Profit adjustments (95.9) (39.0)
Of which Shire acquisition related to unwind of inventories step-up (79.4) (31.1)
Finance income and (expenses), net (143.1) (130.0)
Free cash flow (including announced divestitures) 1,237.8 600.0-700.0
Capital expenditures (cash flow base) (236.5) (210.0 - 260.0)
Depreciation and amortization (excluding intangible assets associated with products) (152.6) (150.0)
Cash tax rate on adjusted EBITDA (excluding divestitures) ~16 % Mid-teen%

10
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
Management Guidance*
The management guidance for the fiscal year ending March 31, 2022 (FY2021) has not been changed from the original guidance (announced at the FY2020 financial results announcement on May 11, 2021).
FY2021
Underlying Revenue Growth Mid-single-digit growth
Underlying Core Operating Profit Growth Mid-single-digit growth
Underlying Core Operating Profit Margin ~30% margin
Underlying Core EPS Growth Mid-single-digit growth
* Please refer to section 1. Financial Highlights for the Three-month Period Ended June 30, 2021, (1) Business Performance, (ii) Underlying Results (April 1 to June 30, 2021), Definition of Core and Underlying Growth.

Other assumptions used in preparing the FY2021 Reported Forecast and the Management Guidance
•To date, Takeda has not experienced a material effect on its financial results as a result of the global spread of the novel coronavirus infectious disease (COVID-19). Based on currently available information, Takeda believes that its financial results for FY2021 will not be materially affected by COVID-19 and, accordingly, Takeda's FY2021 forecast reflects this belief. However, the situation surrounding COVID-19 remains highly fluid, and future COVID-19-related developments in FY2021, including new or additional COVID-19 outbreaks and additional or extended lockdowns, shelter-in-place orders or other government action in major markets, could result in further or more serious disruptions to Takeda's business, such as slowdowns in demand for Takeda's products, supply chain related issues or significant delays in its clinical trial programs. These events, if they occur, could result in an additional impact on Takeda's business, results of operations or financial condition, as well as result in significant deviations from Takeda's FY2021 forecast.
•Takeda expects at least one 505(b)2 competitor for subcutaneous VELCADE to launch in the U.S. around mid FY2021.
•Takeda does not expect to restart sales of NATPARA in the U.S. market in FY2021.
•The forecast and the guidance do not include the impact of any potential further divestitures beyond what has already been disclosed by Takeda.
Forward looking statements
All forecasts in this document are based on information currently available to management, and do not represent a promise or guarantee to achieve these forecasts. Various uncertain factors could cause actual results to differ, such as changes in the business environment and fluctuations in foreign exchange rates. Should any significant event occur which requires the forecast to be revised, the Company will disclose it in a timely manner.

11
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(4) Impact of the Spread of the Novel Coronavirus Infectious Disease (COVID-19) and Takeda's Initiatives in Response
(i) Impact of COVID-19 on Takeda's Operations and Financial Condition
It has been more than a year since the COVID-19 pandemic began, and Takeda continues to respond and provide industry support in a number of ways. While vaccines are becoming more broadly available, we continue to strictly adhere to local public health guidance across our geographies in addition to the existing protocols we have had in place over the past year, and monitor any potential impacts of effects of COVID-19 on our business activities.
In monitoring demand for our products, we have seen limited impact to date as many of our medicines are for severe chronic or life-threatening diseases, without the requirement of a hospital elective procedure. In terms of our global supply chain, based on current assessments, we have not yet seen, nor do we anticipate, any material potential supply distribution issues due to the COVID-19 outbreak.
Since the COVID-19 pandemic began, we have continued voluntary suspensions of certain business activities, including business travel, attending industry events, and holding company-sponsored events. However, and in accordance with local guidelines, we are slowly easing some of these restrictions in some geographies with high rates of vaccinations and low new infection rates. In addition, our field force are resuming a small number of face-to-face engagements with customers, with the majority of all interactions still virtual. Where we are engaging face-to-face, it is only with the agreement of healthcare providers and employees follow strict infection prevention protocols set out by both Takeda and any additional public health and customer requirements.
In the early stages of the global pandemic, we placed a temporary pause on the initiation of the majority of new clinical trial studies. At the same time, for studies already ongoing, we temporarily paused the activation of new study sites and new patient enrollment with a small number of exceptions. This was a short-term action and we have resumed most of our trial activities during the previous fiscal year.
As we continue to monitor developments in the financial markets, we currently do not anticipate any material liquidity or funding-related issues.

(ii) Takeda's Initiatives to Mitigate the Impact of COVID-19
Guided by our values, Takeda's response to COVID-19 continues to focus on protecting the health and safety of our employees, our ability to ensure our medicines are available to patients who rely on them and playing our part to reduce transmission and support the communities where our employees live and work.
Major updates to Takeda's initiatives in response to the spread of COVID-19 in the current period are as below.
•We spent several months evaluating new ways of working to ensure we consider the long-term effects of virtual and hybrid working on our overall people experience and to build an exceptional working environment in a 'post-COVID-19' world. Now we are rolling out a new hybrid working model in parts of Takeda. It will never be a 'one-size-fits-all' approach. Instead, we have created core principles, global guidelines and toolkits to help Takeda leaders and managers determine and implement new hybrid working models for their teams post-COVID.
•Takeda has undertaken a number of efforts to help the world respond to COVID-19. One example is to bring COVID-19 vaccines to Japan through two partnerships. The first partnership is with Novavax, for the development, manufacturing and commercialization of its COVID-19 vaccine candidate NVX CoV2373 (development code in Japan: TAK-019) in Japan. The second partnership is with Moderna and the Government of Japan's Ministry of Health Labour & Welfare (MHLW) to import and distribute its mRNA COVID-19 vaccine (development code in Japan: TAK-919) in Japan. In May 2021, Takeda obtained approval from the MHLW for TAK-919 following positive interim results in Takeda's Phase 1/2 immunogenicity and safety clinical trial, and has since commenced distribution in Japan.Takeda initially entered a three-way agreement with Moderna and MHLW to distribute 50 million doses of TAK-919 in Japan, and in July 2021, Takeda announced an additional three-way agreement to import and distribute an additional 50 million doses from as early as the beginning of 2022, totaling 100 million doses between the two agreements. The agreement of July 2021 includes the potential to secure and supply vaccines corresponding to COVID-19 variants or booster products, should they be successfully developed by Moderna and licensed by the MHLW.

12
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(iii) FY2021 Q1 financial impact from COVID-19
Overall, the global spread of COVID-19 did not have a material effect on our financials for the three-month period ended June 30, 2021. Over the course of the pandemic, there have been adverse effects due to COVID-19 observed in certain therapeutic areas, especially in Neuroscience during periods when stay-at-home restrictions have been in place, reducing patient visits to medical care providers. This was notable especially in the same period of the previous fiscal year when transmission of COVID-19 rapidly expanded across the countries where we operate. The trend has fluctuated since then, and we have not yet seen a full recovery to pre-COVID-19 levels, however, a certain number of our life-saving medicines have shown resilience and have grown even under such an environment.
13
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
2. Condensed Interim Consolidated Financial Statements [IFRS] and Major Notes
(1) Condensed Interim Consolidated Statements of Profit or Loss
JPY (millions, except per share data)
Three-month Period Ended June 30,
2020 2021
Revenue 801,850 949,603
Cost of sales (238,078) (241,264)
Selling, general and administrative expenses (202,374) (219,843)
Research and development expenses (106,821) (122,480)
Amortization and impairment losses on intangible assets associated with products (104,250) (102,824)
Other operating income 63,732 11,118
Other operating expenses (46,774) (25,758)
Operating profit 167,285 248,552
Finance income 19,611 45,851
Finance expenses (46,846) (71,068)
Share of loss of investments accounted for using the equity method (9,759) (357)
Profit before tax 130,291 222,978
Income tax expenses (47,772) (22,558)
Net profit for the period 82,519 200,421
Attributable to:
Owners of the Company 82,511 200,378
Non-controlling interests 8 43
Net profit for the period 82,519 200,421
Earnings per share (JPY)
Basic earnings per share 52.93 128.02
Diluted earnings per share 52.69 127.27
14
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(2) Condensed Interim Consolidated Statements of Comprehensive Income
JPY (millions)
Three-month Period Ended June 30,
2020 2021
Net profit for the period 82,519 200,421
Other comprehensive income (loss)
Items that will not be reclassified to profit or loss:
Changes in fair value of financial assets measured at fair value through other comprehensive income 25,518 15,877
Remeasurement of defined benefit pension plans (2,286) (57)
23,232 15,819
Items that may be reclassified subsequently to profit or loss:
Exchange differences on translation of foreign operations 1,997 27,102
Cash flow hedges (5,126) 12,948
Hedging cost (5,357) 2,230
Share of other comprehensive income (loss) of investments accounted for using the equity method (7) 2
(8,493) 42,281
Other comprehensive income for the period, net of tax 14,739 58,101
Total comprehensive income for the period 97,258 258,521
Attributable to:
Owners of the Company 97,183 258,472
Non-controlling interests 75 49
Total comprehensive income for the period 97,258 258,521
15
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(3) Condensed Interim Consolidated Statements of Financial Position
JPY (millions)
As of March 31, 2021 As of June 30, 2021
ASSETS
Non-current assets:
Property, plant and equipment 1,453,917 1,452,172
Goodwill 4,033,917 4,058,935
Intangible assets 3,909,106 3,856,432
Investments accounted for using the equity method 112,468 115,751
Other financial assets 235,882 258,908
Other non-current assets 100,341 95,022
Deferred tax assets 353,769 343,557
Total non-current assets 10,199,400 10,180,777
Current assets:
Inventories 753,881 779,148
Trade and other receivables 783,091 827,253
Other financial assets 36,598 29,930
Income taxes receivable 29,623 31,704
Other current assets 122,789 133,307
Cash and cash equivalents 966,222 654,920
Assets held for sale 20,689 20,195
Total current assets 2,712,893 2,476,458
Total assets 12,912,293 12,657,234
LIABILITIES AND EQUITY
LIABILITIES
Non-current liabilities:
Bonds and loans 4,613,218 4,381,589
Other financial liabilities 517,677 496,546
Net defined benefit liabilities 158,857 160,871
Income taxes payable 33,690 29,006
Provisions 38,748 35,970
Other non-current liabilities 56,898 58,768
Deferred tax liabilities 542,852 549,559
Total non-current liabilities 5,961,940 5,712,309
Current liabilities:
Bonds and loans 22,153 24,272
Trade and other payables 343,838 320,645
Other financial liabilities 248,053 233,170
Income taxes payable 145,203 138,910
Provisions 471,278 410,300
Other current liabilities 542,651 517,468
Total current liabilities 1,773,176 1,644,766
Total liabilities 7,735,116 7,357,075
16
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
JPY (millions)
As of March 31, 2021 As of June 30, 2021
EQUITY
Share capital 1,668,145 1,669,125
Share premium 1,688,424 1,682,504
Treasury shares (59,552) (42,344)
Retained earnings 1,509,906 1,566,505
Other components of equity 366,114 423,985
Equity attributable to owners of the company 5,173,037 5,299,774
Non-controlling interests 4,140 385
Total equity 5,177,177 5,300,159
Total liabilities and equity 12,912,293 12,657,234

17
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(4) Condensed Interim Consolidated Statements of Changes in Equity
Three-month period ended June 30, 2020 (From April 1 to June 30, 2020)
JPY (millions)
Equity attributable to owners of the company
Share
capital
Share
premium
Treasury
shares
Retained
earnings
Other components of equity
Exchange
differences
on translation
of foreign
operations
Changes in
fair value of
financial
assets
measured at
fair value
through other
comprehensive
income
As of April 1, 2020 1,668,123 1,680,287 (87,463) 1,369,972 91,848 22,891
Net profit for the period 82,511
Other comprehensive income (loss) 1,957 25,484
Comprehensive income (loss) for the period - - - 82,511 1,957 25,484
Transaction with owners:
Issuance of new shares 22 22
Acquisition of treasury shares (2,132)
Disposal of treasury shares (0) 0
Dividends (141,858)
Transfers from other components of equity 19,429 (21,715)
Share-based compensation 10,043
Exercise of share-based awards (28,878) 28,878
Total transactions with owners 22 (18,813) 26,746 (122,429) - (21,715)
As of June 30, 2020 1,668,145 1,661,474 (60,717) 1,330,054 93,805 26,660

Equity attributable to owners of the company
Other components of equity
Cash flow
hedges
Hedging
cost
Remeasurements of defined benefit pension plans Total Total Non-
controlling
interests
Total
equity
As of April 1, 2020 (22,730) 555 - 92,564 4,723,483 4,003 4,727,486
Net profit for the period - 82,511 8 82,519
Other comprehensive income (loss) (5,126) (5,357) (2,286) 14,672 14,672 67 14,739
Comprehensive income (loss) for the period (5,126) (5,357) (2,286) 14,672 97,183 75 97,258
Transaction with owners:
Issuance of new shares - 44 44
Acquisition of treasury shares - (2,132) (2,132)
Disposal of treasury shares - 0 0
Dividends - (141,858) (77) (141,935)
Transfers from other components of equity 2,286 (19,429) - -
Share-based compensation - 10,043 10,043
Exercise of share-based awards - (0) (0)
Total transactions with owners - - 2,286 (19,429) (133,903) (77) (133,980)
As of June 30, 2020 (27,856) (4,802) - 87,807 4,686,763 4,001 4,690,764
18
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
Three-month period ended June 30, 2021 (From April 1 to June 30, 2021)
JPY (millions)
Equity attributable to owners of the company
Share
capital
Share
premium
Treasury
shares
Retained
earnings
Other components of equity
Exchange
differences
on translation
of foreign
operations
Changes in
fair value of
financial
assets
measured at
fair value
through other
comprehensive
income
As of April 1, 2021 1,668,145 1,688,424 (59,552) 1,509,906 400,798 41,983
Net profit for the period 200,378
Other comprehensive income (loss) 27,029 15,944
Comprehensive income (loss) for the period - - - 200,378 27,029 15,944
Transaction with owners:
Issuance of new shares 980 6,898
Acquisition of treasury shares (4,464)
Disposal of treasury shares (0) 0
Dividends (141,859)
Changes in ownership (2,143)
Transfers from other components of equity 224 (281)
Share-based compensation 8,547
Exercise of share-based awards (21,365) 21,671
Total transactions with owners 980 (5,919) 17,208 (143,779) - (281)
As of June 30, 2021 1,669,125 1,682,504 (42,344) 1,566,505 427,827 57,646

Equity attributable to owners of the company
Other components of equity
Cash flow
hedges
Hedging
cost
Remeasurements of defined benefit pension plans Total Total Non-
controlling
interests
Total
equity
As of April 1, 2021 (68,075) (8,592) - 366,114 5,173,037 4,140 5,177,177
Net profit for the period - 200,378 43 200,421
Other comprehensive income (loss) 12,948 2,230 (57) 58,094 58,094 7 58,101
Comprehensive income (loss) for the period 12,948 2,230 (57) 58,094 258,472 49 258,521
Transaction with owners:
Issuance of new shares - 7,878 7,878
Acquisition of treasury shares - (4,464) (4,464)
Disposal of treasury shares - 0 0
Dividends - (141,859) (141,859)
Changes in ownership - (2,143) (3,804) (5,948)
Transfers from other components of equity 57 (224) - -
Share-based compensation - 8,547 8,547
Exercise of share-based awards - 307 307
Total transactions with owners - - 57 (224) (131,734) (3,804) (135,539)
As of June 30, 2021 (55,126) (6,362) - 423,985 5,299,774 385 5,300,159
19
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(5) Condensed Interim Consolidated Statements of Cash Flows
JPY (millions)
Three-month Period Ended June 30,
2020 2021
Cash flows from operating activities:
Net profit for the period 82,519 200,421
Depreciation and amortization 141,587 142,948
Impairment losses 7,458 53
Equity-settled share-based compensation 10,043 8,547
Change in estimate of liabilities related to SHP647 (60,179) -
Loss on sales and disposal of property, plant and equipment 300 94
Gain on divestment of business and subsidiaries (365) (365)
Change in fair value of financial assets and liabilities associated with contingent consideration arrangements, net 19,297 (934)
Finance (income) and expenses, net 27,235 25,216
Share of loss of investments accounted for using the equity method 9,759 357
Income tax expenses 47,772 22,558
Changes in assets and liabilities:
Increase in trade and other receivables (25,845) (41,835)
Increase in inventories (4,367) (21,009)
Decrease in trade and other payables (23,153) (24,854)
Increase (decrease) in provisions 2,177 (65,217)
Increase (decrease) in other financial liabilities 685 (7,985)
Other, net (37,579) (35,236)
Cash generated from operations 197,344 202,760
Income taxes paid (51,483) (35,902)
Net cash from operating activities 145,861 166,858
Cash flows from investing activities:
Interest received 308 349
Dividends received 177 139
Acquisition of property, plant and equipment (23,135) (29,838)
Proceeds from sales of property, plant and equipment 26 79
Acquisition of intangible assets (17,342) (12,454)
Acquisition of investments (3,517) (3,251)
Proceeds from sales and redemption of investments 44,437 483
Acquisition of businesses, net of cash and cash equivalents acquired - (27,549)
Proceeds from sales of business, net of cash and cash equivalents divested - 2,138
Other, net (292) (543)
Net cash from (used in) investing activities 662 (70,445)
20
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
JPY (millions)
Three-month Period Ended June 30,
2020 2021
Cash flows from financing activities:
Net increase (decrease) in short-term loans and commercial papers (10,000) 1
Repayments of bonds and long-term loans (9,979) (242,919)
Acquisition of treasury shares (2,132) (2,542)
Interest paid (30,207) (23,218)
Dividends paid (133,115) (132,032)
Repayments of lease liabilities (7,213) (10,328)
Other, net (119) -
Net cash used in financing activities (192,765) (411,038)
Net decrease in cash and cash equivalents (46,242) (314,625)
Cash and cash equivalents at the beginning of the year
(Consolidated statements of financial position) 637,614 966,222
Effects of exchange rate changes on cash and cash equivalents (1,585) 3,324
Cash and cash equivalents at the end of the period
(Consolidated statements of financial position) 589,787 654,920

21
Takeda Pharmaceutical Company Limited (4502)
Summary of Financial Statements for the Three-month
Period Ended June 30, 2021 (Consolidated)
(6) Notes to Condensed Interim Consolidated Financial Statements
(Significant Uncertainty Regarding Going Concern Assumption)
Three-month period ended June 30, 2021 (April 1 to June 30, 2021)
Not applicable.
(Significant Accounting Policies)
Significant accounting policies adopted for the condensed interim consolidated financial statements are the same as those adopted for the consolidated financial statements of the fiscal year ended March 31, 2021.
Takeda calculated income tax expenses for the three-month period ended June 30, 2021, based on the estimated average annual effective tax rate.
(Significant Changes in Equity Attributable to Owners of the Company)
Three-month period ended June 30, 2021 (April 1 to June 30, 2021)
Not applicable.
(Significant Subsequent Events)
On July 9, 2021, Takeda provided a notice of redemption to the holders of 1,500 million EUR in unsecured senior notes issued in November 2018 in advance of their original maturity date of November 21, 2022. The redemption date of the unsecured senior notes will be August 10, 2021.
The impact from the accelerated debt prepayment on the consolidated statements of profit or loss is not expected to be material.
22

APPENDIX
1 FY2021 Q1 Reconciliation from Reported Revenue to Core/Underlying Revenue
2 FY2021 Q1 Reconciliation from Reported to Core/Underlying Core
3 FY2020 Q1 Reconciliation from Reported to Core/Underlying Core


1 FY2021 Q1 Reconciliation from Reported Revenue to Core/Underlying Revenue
Q1
(Billion JPY)
FY2020
FY2021
vs. PY
Reported Revenue 801.9 949.6 +147.8 + 18.4%
Sale of Japan diabetes portfolio*2
- (133.0) (133.0) -16.6pp
Core Revenue 801.9 816.6 +14.7 + 1.8%
FX effects*1
-3.9pp
Divestitures*2
+5.8pp
Regional portfolio +1.6pp
Japan diabetes portfolio +1.1pp
TACHOSIL +0.4pp
Others +2.8pp
Underlying Revenue Growth + 3.8%

*1 FX adjustment applies plan rate to both periods.
*2 Major adjustments are as follow;
•Revenue of select over-the-counter and non-core products in Asia Pacific is excluded from FY2020 Q1 as the divestiture was completed in November 2020.
•Revenue of select non-core prescription pharmaceutical products predominantly in Europe is excluded from FY2020 Q1 as the divestiture was completed in December 2020.
•Revenue of select over-the-counter and non-core products in Latin America is excluded from FY2020 Q1 as the divestiture was completed in January 2021.
•Net sales from TACHOSIL, a surgical patch, are excluded from FY2020 Q1 as the divestiture was completed in January 2021.
•Revenue of select over-the-counter and non-core products predominantly in Europe is excluded from FY2020 Q1 as the divestiture was completed in March 2021.
•Revenue of the former subsidiary, Takeda Consumer Healthcare Company Limited is excluded from FY2020 Q1 as the divestiture was completed in March 2021.
•Net sales from a portfolio of diabetes products in Japan (NESINA, LIOVEL, INISYNC and ZAFATEK) are excluded from FY2020 Q1 as the divestiture was completed at the beginning of April 2021. In addition, the non-recurring item of the 133.0 billion JPY selling price as the result of the completion of the divestiture is excluded from FY2021 Q1.
•Revenue of select non-core prescription pharmaceutical products in China is excluded from both FY2021 Q1 and FY2020 Q1 as the divestiture was publicly announced and had been expected to complete within FY2021 H1.



2 FY2021 Q1 Reconciliation from Reported to Core/Underlying Core
FY2021Q1
(Billion JPY) REPORTED REPORTED TO CORE ADJUSTMENTS CORE CORE TO
UNDERLYING CORE ADJ.
UNDERLYING
GROWTH
Amortization of
intangible
assets
Impairment of
intangible
assets
Other
operating income/
expense
Sale of Japan diabetes portfolio Others FX Divestitures
Revenue 949.6 (133.0) 816.6 (31.5) (3.9) +3.8 %
Cost of sales (241.3) 0.6 12.8 (227.9) 10.6 1.4
Gross Profit 708.3 (132.4) 12.8 588.7 (20.9) (2.5)
SG&A expenses (219.8) 1.0 0.9 (218.0) 8.7
R&D expenses (122.5) 0.7 (121.8) 4.1
Amortization of intangible assets (102.8) 102.8 -
Impairment losses on intangible assets - -
Other operating income 11.1 (10.8) (0.4) -
Other operating expenses (25.8) 25.1 0.7 -
Operating profit 248.6 102.8 14.3 (131.4) 14.7 248.9 (8.1) (2.5) (2.1) %
Margin 26.2 % 30.5 % 30.5 %*
Financial income/expenses (25.2) (2.5) (27.7) 1.3
Equity income/loss (0.4) 2.3 2.0 0.1
Profit before tax 223.0 102.8 14.3 (131.4) 14.5 223.2 (6.7) (2.5)
Tax expenses (22.6) (22.9) (4.8) 40.2 (36.5) (46.6) 1.4 0.8
Non-controlling interests (0.0 ) (0.0 ) 0.0
Net profit 200.4 79.9 9.5 (91.2) (22.0) 176.6 (5.3) (1.7)
EPS (yen) 128 113 (3) (1) +3.9 %
Number of shares (millions) 1,565 1,565 1,563

* Underlying Core Operating Profit Margin.



3 FY2020 Q1 Reconciliation from Reported to Core/ Underlying Core
FY2020Q1
(Billion JPY) REPORTED REPORTED TO CORE ADJUSTMENTS CORE CORE TO
UNDERLYING CORE ADJ.
UNDERLYING
GROWTH
Amortization of
intangible
assets
Impairment of
intangible
assets
Other
operating income/
expense
TEVA JV related accounting adjustments Others FX Divestitures
Revenue 801.9 801.9 (0.7) (48.7) +0.9 %
Cost of sales (238.1) 26.6 (211.5) (6.5) 13.5
Gross Profit 563.8 26.6 590.3 (7.1) (35.2)
SG&A expenses (202.4) 0.0 (0.3) (202.6) 0.5 3.5
R&D expenses (106.8) (0.1) 0.1 (106.8) 0.8 0.2
Amortization of
intangible assets
(102.3) 102.3 -
Impairment losses on intangible assets (1.9) 1.9 -
Other operating income 63.7 (3.2) (0.4) (60.2) -
Other operating expenses (46.8) 28.2 18.6 -
Operating profit 167.3 102.3 1.9 24.9 (0.4) (15.2) 280.9 (5.9) (31.5) +11.2 %
Margin 20.9 % 35.0 % 32.4 %*
Financial income/expenses (27.2) (1.1) (28.3) (0.4) (0.0)
Equity income/loss (9.8) 10.6 0.8 0.0
Profit before tax 130.3 102.3 1.9 24.9 10.2 (16.3) 253.4 (6.2) (31.5)
Tax expenses (47.8) (19.7) (0.3) (2.6) (3.1) 10.8 (62.7) 1.6 8.8
Non-controlling interests (0.0 ) (0.0 ) (0.0 )
Net profit 82.5 82.6 1.6 22.3 7.1 (5.5) 190.6 (4.7) (22.7)
EPS (yen) 53 122 (3) (15) +8.7 %
Number of shares
(millions)
1,559 1,559 1,558
* Underlying Core Operating Profit Margin.



Important Notice
For the purposes of this notice, 'report' means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited ('Takeda') regarding this release. This report (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this report. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This report is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.
The companies in which Takeda directly and indirectly owns investments are separate entities. In this report, 'Takeda' is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words 'we', 'us' and 'our' are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

The product names appearing in this document are trademarks or registered trademarks owned by Takeda, or their respective owners.
Forward-Looking Statements
This report and any materials distributed in connection with this report may contain forward-looking statements, beliefs or opinions regarding Takeda's future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as 'targets', 'plans', 'believes', 'hopes', 'continues', 'expects', 'aims', 'intends', 'ensures', 'will', 'may', 'should', 'would', 'could' 'anticipates', 'estimates', 'projects' or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda's global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda's operations and the timing of any such divestment(s); and other factors identified in Takeda's most recent Annual Report on Form 20-F and Takeda's other reports filed with the U.S. Securities and Exchange Commission, available on Takeda's website at: https://www.takeda.com/investors/sec-filings/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this report or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this report may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda's future results.
Certain Non-IFRS Financial Measures
This report includes certain non-IFRS financial measures and targets. Takeda's management evaluates results and makes operating and investment decisions using both IFRS and non-IFRS measures included in this report. Non-IFRS results exclude certain income and cost items which are included in IFRS results. By including these non-IFRS measures, management intends to provide investors with additional information to further analyze Takeda's performance, core results and underlying trends. Non-IFRS results are not prepared in accordance with IFRS and non-IFRS information should be considered a supplement to, and not a substitute for, financial statements prepared in accordance with IFRS. Investors are encouraged to review the reconciliations of non-IFRS financial measures to their most directly comparable IFRS measures, which are on appendices 1-3.
Medical information
This report contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.
Financial information
Takeda's financial statements are prepared in accordance with International Financial Reporting Standards ('IFRS').

Disclaimer

Takeda Pharmaceutical Co. Ltd. published this content on 30 July 2021 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 30 July 2021 12:08:30 UTC.


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Net income 2022 253 B 2 295 M 2 295 M
Net Debt 2022 3 472 B 31 450 M 31 450 M
P/E ratio 2022 23,4x
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Christophe Weber President, CEO & Representative Director
Constantine Saroukos Chief Financial Officer & Director
Andrew S. Plump Director, Research & Development President
Michael E. Mendelsohn Chief Medical & Scientific Officer
Norimasa Takeda Chief Accounting Officer & Corporate Controller
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