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    SGEN   US81181C1045

SEAGEN INC.

(SGEN)
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Seagen to Highlight New Data in Advanced Breast Cancer at 2021 San Antonio Breast Cancer Symposium

11/19/2021 | 09:33am EST

Seagen Inc. announced upcoming data presentations for TUKYSA? (tucatinib) at the San Antonio Breast Cancer Symposium (SABCS), taking place December 7-10, 2021. Seven abstracts including three spotlight posters - highlight the company?s commitment to addressing unmet needs in advanced breast cancer. Two abstracts featured in spotlight poster presentations show: Continued Clinical Benefit in HER2-Positive Metastatic Breast Cancer Patients (MBC) with Active and Stable Brain Metastases. Updated exploratory results from the pivotal HER2CLIMB trial showed that TUKYSA combined with trastuzumab and capecitabine resulted in a robust and durable prolongation of overall survival (OS) that was consistent with results from the primary analysis for HER2-positive metastatic breast cancer patients with brain metastases after an additional 15.6 months of follow-up. The benefit was maintained in patients with active and stable brain metastases. These results will be featured in a spotlight poster (Abstract #PD4-04) presented by Nancy U. Lin, M.D., Director of the Metastatic Breast Cancer Program in the Susan F. Smith Center for Women?s Cancers at Dana-Farber in Boston, MA. Promising Activity of TUKYSA Regimen in HER2-Positive MBC Patients with Leptomeningeal Metastases: A single-arm, investigator-sponsored phase 2 trial (n=17) of TUKYSA combined with trastuzumab and capecitabine represents the first prospective evidence of a systemic regimen demonstrating clinical benefit for HER2-positive breast cancer patients with leptomeningeal metastases, cancer that has spread to the membranes lining the brain and spinal cord. The findings showed a median OS of nearly one year (11.9 months [95% Confidence Interval: 4.1, NR]). Patients with leptomeningeal disease have a historically poor prognosis with median survival of four to five months. The most common treatment for leptomeningeal metastases is radiation therapy. These results will be featured in a spotlight poster (Abstract #PD4-02) presented by Rashmi Murthy, M.D., University of Texas MD Anderson Cancer Center. Patients with HER2-positive breast cancer have tumors with high levels of a protein called human epidermal growth factor receptor 2 (HER2), which promotes the growth of cancer cells. Up to 50% of metastatic HER2-positive breast cancer patients develop brain metastases over time. In 2020, more than two million new cases of breast cancer were diagnosed worldwide. Between 15% and 20% of breast cancer cases are HER2-positive.


ę S&P Capital IQ 2021
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Analyst Recommendations on SEAGEN INC.
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Financials (USD)
Sales 2021 1 549 M - -
Net income 2021 -647 M - -
Net cash 2021 2 348 M - -
P/E ratio 2021 -34,5x
Yield 2021 -
Capitalization 22 475 M 22 475 M -
EV / Sales 2021 13,0x
EV / Sales 2022 9,35x
Nbr of Employees 2 092
Free-Float 99,3%
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Mean consensus OUTPERFORM
Number of Analysts 21
Last Close Price 122,91 $
Average target price 189,89 $
Spread / Average Target 54,5%
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Managers and Directors
Clay B. Siegall Director & Chief Scientific Officer
Todd E. Simpson Chief Financial Officer
Vaughn B. Himes Chief Technical Officer
Roger D. Dansey Chief Medical Officer
Marc E. Lippman Independent Director
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