LEXINGTON, Mass. - LogicBio Therapeutics, Inc. (Nasdaq:LOGC), a clinical-stage genetic medicine company pioneering gene editing and gene delivery platforms to address rare and serious diseases from infancy through adulthood, reported financial results for the second quarter ended June 30, 2021 and highlighted recent corporate milestones.
'LogicBio made significant progress in the first half of the year. Most importantly, we dosed the first patient in our groundbreaking Phase 1/2 SUNRISE trial, which we believe represented the first in vivo gene editing therapy delivered systemically to a pediatric patient,' said Frederic Chereau, president and chief executive officer of LogicBio Therapeutics. 'We also entered into collaborations with Daiichi Sankyo and CANbridge Pharmaceuticals, which represented a validation of the potential of our GeneRide and sAAVy platforms. The second quarter also saw us strengthen our leadership team with key executive appointments. I am confident this progress positions us well to expand our platforms and pipeline. We continue to look forward to providing an update on SUNRISE enrollment, highlighting dose escalation and age de-escalation, expected later in the year, as well as interim data from the SUNRISE trial, expected by year-end.'
Anticipated Milestones for 2021:
Ph 1/2 SUNRISE Trial for LB-001 in Pediatric Patients with MMA
Late 2021: Provide update on enrollment, including dose escalation and age de-escalation
Year-end 2021: Announce interim clinical data
Year-end 2021: Nomination of next development candidate Recent Business Highlights:
First patient dosed in Phase 1/2 SUNRISE clinical trial for LB-001 for the treatment of MMA in pediatric patients
In June, LogicBio announced it dosed its first patient in its Phase 1/2 SUNRISE clinical trial for the treatment of pediatric patients with MMA. The SUNRISE trial is initially enrolling patients 3-12 years old and will potentially enroll infants as young as 6 months once the first two patients meet certain safety parameters and a biomarker indicating genome integration and protein expression is detected.
Entered into collaborations with Daiichi Sankyo and CANbridge Pharmaceuticals
In April, LogicBio entered into a research collaboration with Daiichi Sankyo to develop treatments for two indications based on the Company's GeneRide platform.
In April, LogicBio entered into a strategic collaboration and option agreement with CANbridge Pharmaceuticals (CANbridge) under which LogicBio granted CANbridge a license to certain intellectual property rights, including those relating to adeno-associated virus sL65 (sL65), the first capsid produced from LogicBio's sAAVy platform, for the development and commercialization of gene therapy candidates for the treatment of Fabry and Pompe diseases. LogicBio also granted CANbridge exclusive options to license certain intellectual property rights, including those relating to sL65, for the development and commercialization of gene therapy candidates for two additional indications, and to license LB-001 for the treatment of MMA in Greater China. In addition, under the terms of the agreement, LogicBio and CANbridge will collaborate to develop the gene therapy candidates for the treatment of Fabry and Pompe diseases and, upon CANbridge's exercise of the applicable options, two additional indications, under a mutually agreed research plan.
Preclinical data presented at ASGCT
In May, the Company presented preclinical data that highlighted the significant potential of the Company's GeneRide and sAAVy platforms at the 24th Annual American Society of Gene and Cell Therapy (ASGCT) Virtual Meeting.
Strengthened leadership team with key appointments
In May, LogicBio announced the following appointments to its leadership team: Daniel Gruskin, M.D., as chief medical officer, Andrea Paul, as general counsel and corporate secretary, Janice Olson, as senior vice president of portfolio strategy and management, Stephen Boyer, Ph.D., as vice president of regulatory and quality affairs, and Peter Pechan, Ph.D., as vice president of gene therapy.
Second Quarter 2021 Financial Results:
Revenue: Revenue for the three months ended June 30, 2021 was $0.8 million, compared to $1.0 million for the three months ended June 30, 2020. The decrease in revenue during the three months ended June 30, 2021 compared to the corresponding period in 2020 was related to winding down activities under the January 2020 Takeda agreement, which was partially offset by revenue recognized under the April 2021 CANbridge and Daiichi Sankyo agreements.
R&D Expenses: Research and development expenses for the three months ended June 30, 2021 were $7.3 million, compared to $5.9 million for the three months ended June 30, 2020. The increase of approximately $1.4 million was primarily due to an increase of $0.8 million in personnel-related costs as the Company increased its headcount as well as an increase of $1.2 million in other research and development costs, primarily driven by intellectual property licensing obligations due to certain of the Company's licensors. These increases were partially offset by a decrease of $0.6 million in LB-001 external development and manufacturing costs.
G&A Expenses: General and administrative expenses were $3.8 million for the three months ended June 30, 2021, compared to $3.0 million for the three months ended June 30, 2020. The increase of approximately $0.7 million was primarily driven by an increase of $0.4 million in personnel expenses, including a $0.1 million increase in stock-based compensation expense as the Company increased its headcount.
Net Loss: Net loss for the three months ended June 30, 2021 was $10.5 million or $0.33 per share, compared to a net loss of $8.2 million, or $0.35 per share, for the three months ended June 30, 2020.
Cash Position: As of June 30, 2021, LogicBio had cash and cash equivalents of $68.1 million as compared to $63.9 million as of March 31, 2021. The increase was driven by the upfront payments received as part of the collaborations with CANbridge and Daiichi Sankyo, and partially offset by cash used in operating activities during the quarter. As of June 30, 2021, LogicBio had 32,222,366 shares outstanding.
Financial Guidance: The Company expects its cash and cash equivalents to fund its current operating plan for at least the next twelve months from the date of this press release.
About the SUNRISE Trial
The SUNRISE trial is an open-label, multi-center, Phase 1/2 clinical trial designed to assess the safety and tolerability of a single intravenous infusion of LB-001 in pediatric patients with methylmalonic acidemia (MMA) characterized by methylmalonyl-CoA mutase gene (MMUT) mutations. On June 2, 2021, the Company announced that the first patient was dosed. Seven leading centers in the United States and one in Saudi Arabia are expected to participate in the trial. With the aim of evaluating LB-001 at an early age, before irreversible damage has occurred, the SUNRISE trial is initially enrolling 3-12 year old patients with the potential to include infants as young as 6 months old after meeting certain safety parameters and biomarker detection indicating genome integration and protein expression. The SUNRISE trial will enroll up to eight patients and evaluate a single administration of LB-001 at two dose levels.
LB-001 is an investigational, first-in-class, single-administration, gene editing therapy for early intervention in methylmalonic acidemia (MMA) using the GeneRide platform. GeneRide technology utilizes a natural DNA repair process called homologous recombination that enables precise editing of the genome without the need for exogenous nucleases and exogenous promoters that are associated with an increased risk of immune response and cancer. LB-001 is designed to non-disruptively insert a corrective copy of the methylmalonyl-CoA mutase (MMUT) gene into the albumin locus to drive lifelong therapeutic levels of MMUT expression in the liver, the main site of MMUT expression and activity. LB-001 is delivered to hepatocytes via liver-targeted, engineered recombinant adeno-associated virus vector (rAAV-LK03). Preclinical studies found that LB-001 was safe and demonstrated transduction of hepatocytes, site-specific genomic integration, and transgene expression. LB-001-corrected hepatocytes in a mouse model of MMA demonstrated preferential survival and expansion (selective advantage), thus contributing to a progressive increase in hepatic MMUT expression over time. LB-001 resulted in improved growth, metabolic stability, and survival in MMA mice. The U.S. Food and Drug Administration (FDA) granted fast track designation, rare pediatric disease designation and orphan drug designation for LB-001 for the treatment of MMA. In addition, the European Medicines Agency (EMA) granted orphan drug designation for LB-001 for the treatment of MMA.
About Methylmalonic Acidemia (MMA)
Methylmalonic acidemia (MMA) is a rare and life-threatening genetic disorder affecting approximately 1 in 50,000 newborns in the United States. In the most common form of MMA, a mutation in a gene called methylmalonyl-CoA mutase (MMUT) prevents the body from properly processing certain fats and proteins. As a result, toxic metabolites accumulate in the liver, in muscle tissue and in the brain. Symptoms include vomiting, lethargy, seizures, developmental delays and organ damage. There is no approved medical therapy addressing the underlying cause of the disease. To manage the symptoms, patients go on a severely restrictive, low-protein, high-calorie diet, often through a feeding tube. Even with aggressive management, these patients often experience life-threatening metabolic crises that can cause permanent neurocognitive damage. Because of the need for early intervention, newborns are screened for MMA in every state in the United States.
About LogicBio Therapeutics
LogicBio Therapeutics is a clinical-stage genetic medicine company pioneering gene editing and gene delivery platforms to address rare and serious diseases from infancy through adulthood. The Company's gene editing platform, GeneRide, is a new approach to precise gene insertion harnessing a cell's natural DNA repair process potentially leading to durable therapeutic protein expression levels. The Company's gene delivery platform, sAAVy, is an adeno-associated virus (AAV) capsid engineering platform designed to optimize gene delivery for treatments in a broad range of indications and tissues. The Company is based in Lexington, MA. For more information, visit www.logicbio.com, which does not form a part of this release.
Statements in this press release regarding LogicBio's strategy, plans, prospects, expectations, beliefs, intentions and goals are forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995, as amended, including but not limited to statements regarding dosing representing the first in vivo gene editing therapy delivered systemically to a pediatric patient; the expected timing of providing an update on enrollment, dose escalation and age de-escalation in the SUNRISE trial; the expected timing of announcing interim clinical data in the SUNRISE trial; being well-positioned to continue to expand our platforms and pipeline; our anticipated milestones and the timing thereof; enrolling patients as young as 6 months old in the SUNRISE trial; the potential benefits of LB-001; and the sites expected to participate in the SUNRISE trial. The terms 'anticipate,' 'believe,' 'confident,' 'expect,' 'look forward,' 'on track,' 'positions us,' 'potential,' 'will' and similar references are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Each forward-looking statement is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statement, including the potential direct or indirect impact of the COVID-19 pandemic on our business, operations, and the markets and communities in which we and our partners, collaborators and vendors operate; the risk that existing preclinical data may not be predictive of the results of ongoing or later clinical trials; the risks that clinical trials may not be successful or may be discontinued or delayed for any reason; manufacturing and process development risks, including delays relating to continuously improving our manufacturing processes; risks associated with management and key personnel changes and transitional periods; the actual funding required to develop and commercialize product candidates, including for safety, tolerability, enrollment, manufacturing or economic reasons; the timing and content of decisions made by regulatory authorities; the actual time it takes to initiate and complete preclinical and clinical studies; the competitive landscape; changes in the economic and financial conditions of LogicBio; and LogicBio's ability to obtain, maintain and enforce patent and other intellectual property protection for LB-001 and any other product candidates. Other risks and uncertainties include those identified under the heading 'Risk Factors' in LogicBio's Annual Report on Form 10-K for the year ended December 31, 2020 and other filings that LogicBio may make with the U.S. Securities and Exchange Commission in the future. These forward-looking statements (except as otherwise noted) speak only as of the date of this press release, and LogicBio does not undertake, and specifically disclaims, any obligation to update any forward-looking statements contained in this press release.
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