Nov 23 (Reuters) - The top U.S. infectious disease medical
association said on Monday that Gilead Sciences Inc's
antiviral drug remdesivir should be used for hospitalized
COVID-19 patients despite a World Health Organization (WHO)
recommendation last week against its use.
The Infectious Diseases Society of America (IDSA) in updated
guidelines said its experts back the drug for use in severe
COVID-19 patients based on a clinical trial showing it reduced
hospital stays. The WHO study that led to its recommendation
against the drug suggested it had no benefit in saving lives or
reducing the need for mechanical breathing assistance.
"As hospitals around the United States fill up, the IDSA
panel views the effect of remdesivir speeding up time to
recovery to be an important benefit," Dr. Rajesh Gandhi,
co-chair of the society's COVID-19 treatment and management
guidelines expert panel, said on a call with reporters. "Better
medicines that improve survival are clearly needed."
Unlike the trial that led to its U.S. regulatory approval,
the WHO's study was not placebo-controlled. Studies with a
placebo comparison are generally considered more scientifically
rigorous than those without a control group.
The IDSA also has advised against the routine use of Eli
Lilly and Co's COVID-19 antibody treatment bamlanivimab,
which received U.S. emergency use authorization. The IDSA panel
said it recommended against its routine use for ambulatory
patients, but that it may still be appropriate for patients with
increased risks after a discussion with their doctor.
"Antibodies may end up having a role. I think we just need
more definitive data," Dr. Gandhi said. "I want to keep our eye
on what benefit they may end up having as well as which patients
are most likely to benefit."
It said Roche Holdings Ag's rheumatoid arthritis
drug Actemra, known chemically as tocilizumab, is not
recommended for routine use in hospitalized COVID-19 patients,
saying there was still not enough evidence supporting its
benefits.
(Reporting by Rebecca Spalding
Editing by Bill Berkrot)