BioArctic AB (publ) gave an update on the company's development project ND3014. For the first time, it was announced that the project aims to develop selective antibody treatments targeting TDP-43, a protein that is believed to play a crucial role in the development of the rare neurodegenerative disease ALS. ALS (amyotrophic lateral sclerosis) is a devastating neurodegenerative disease that affects the body's ability to control muscle activity. TDP-43 (TAR DNA-binding protein 43) is a key protein that impacts the disease development. When this protein is misfolded, it creates toxic aggregates, causing a stepwise degeneration of motor neurons in the brain, the brain stem, and the spinal cord. Aggregates of TDP-43 in the central nervous system is a common clinical finding in ALS, found in most cases of patients in studies. Misfolded TDP-43 has also been shown in many patients with frontotemporal dementia and Alzheimer's disease. The aim of BioArctic's development of selective antibody treatments toward TDP-43 is to decrease the levels of the toxic TDP-43 aggregates in nerve cells, and thus achieve a disease-modifying effect.