Johnson & Johnson ended up 0.5%, but off earlier highs, after it began shipping its single-dose vaccine after it became the third authorized COVID-19 vaccine in the United States over the weekend.
President Joe Biden scored his first legislative win as the House of Representatives passed his $1.9 trillion coronavirus relief package early Saturday. The bill now moves to the Senate.
U.S. bond yields eased after a swift rise last month on expectations of accelerated inflation due to bets on an economic rebound. The U.S. 10-year treasury yield dipped to 1.449% after hitting a one-year high of 1.614%. [US/]
"The sentiment is risk-on with more investors showing interest towards cyclical stocks while a positive vaccination drive and better macro numbers are hinting towards a better growth environment," said Keith Buchanan, portfolio manager at Globalt in Atlanta.
Data showed U.S. manufacturing activity increased to a three-year high in February amid an acceleration in new orders.
All 11 S&P 500 sectors rallied, led by financials and technology.
Apple Inc, Microsoft Corp, Facebook Inc and Amazon.com Inc bounced back after a selloff last week in tech stocks. Apple rose over 5% and was the strongest contributor to the S&P 500's gains.
In extended trade, Zoom Video Communications jumped 10% following its quarterly report.
The S&P 500's rebound from its 50-day moving average, touched after Friday's decline, is a bullish sign that is adding to investors' enthusiasm, said CFRA Research Chief Investment Strategist Sam Stovall.
"It's a positive signal, at least in the near term, that the recent weakness has dissipated," Stovall said.
The Dow Jones Industrial Average surged 1.95% to end at 31,535.51 points, while the S&P 500 gained 2.38% to 3,901.82.
The Nasdaq Composite jumped 3.01% to 13,588.83.
The Russell 2000 index of smaller companies surged 3.37%, putting its gain in 2021 at over 15%, compared with the S&P 500's gain of about 4% in the same period.
Boeing Co jumped 5.8% after United Airlines Holdings Inc ordered 25 new 737 MAX aircraft and moved up the delivery of others as it prepares to replace aging jets and meet expected post-pandemic growth in demand.
Warren Buffett's enthusiasm for the future of the United States and his company Berkshire Hathaway Inc has not been dimmed by the coronavirus pandemic, according to his annual letter to investors. Berkshire's shares rallied 3.6%.
Perrigo Co Plc jumped 4.7% as the consumer healthcare products company said it would sell its underperforming generic drugs business for $1.55 billion.
Advancing issues outnumbered declining ones on the NYSE by a 3.81-to-1 ratio; on Nasdaq, a 4.29-to-1 ratio favored advancers.
The S&P 500 posted 48 new 52-week highs and no new lows; the Nasdaq Composite recorded 197 new highs and 17 new lows.
Volume on U.S. exchanges was 12.1 billion shares, compared with the 15.1 billion average for the full session over the last 20 trading days.
(Reporting by Noel Randewich; Additional reporting by Medha Singh and Shashank Nayar in Bengaluru; Editing by Lisa Shumaker)
By Noel Randewich