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MarketScreener Homepage  >  Equities  >  Euronext Paris  >  AB Science    AB   FR0010557264

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Science : Webconference presentation on masitinib in mastocytosis

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12/02/2019 | 03:50pm EDT

AB SCIENCE WEBCONFERENCE

MASITINIB IN SEVERE ASTHMA UNCONTROLLED BY ORAL COTICOSTEROIDS

02 December 2019

Disclaimer

This presentation, together with the material set forth herein, does not constitute an offer of securities for sale nor the solicitation of an offer to purchase securities in any jurisdiction. Distribution of such presentation in certain jurisdiction may constitute a breach of applicable laws and regulation.

This document is solely for your information on a confidential basis and may not be reproduced, redistributed or sent, in whole or in part, to any other person, including by email or by any other means of electronic communication. In particular, neither this document nor any copy of it may be taken, transmitted or distributed, directly or indirectly, in the United States, Canada, Japan or Australia. The distribution of this document in other jurisdictions may be restricted by law and persons into whose possession this document comes should make themselves aware of the existence of, and observe, any such restrictions.

Neither the Company, nor any of its advisors and representatives may accept any responsibility for any loss or damage incurred by the use of this document or the information set forth herein. Neither the Company, nor any of its advisors and representatives takes any undertaking nor guarantees, whether explicitly or tacitly, the accuracy or the completeness of the information set forth herein. Neither this document, nor any part of it, shall form the basis of, or be relied upon in connection with, any contract or commitment whatsoever.

In particular, in France, any decision to purchase such securities shall rely solely on the documents that have been reviewed by the Autorité des Marchés Financiers (the "AMF") and/or published by the Company.

This document does not constitute an offer to purchase any financial instruments in the United States. Securities mentioned in this document have not been and will not be registered under the Securities Act of 1933, as amended (the "Securities Act") and may not be offered or sold in the United States absent registration or an exemption from the registration requirements of the Securities Act. The Company does not intend to register any offering in all or in part or to make a public offer of securities in the United States.

This document contains information on the objectives of the Company along with some projections and forward-looking statements. The reader's attention is drawn to the fact that these objectives may not be fulfilled, and the forecasts or information provided may prove erroneous, and the Company is not required to update such information. Past performance is no guide to future performance and persons needing advice should consult an independent financial adviser.

By attending this presentation or reading this document, you agree to be bound by the limitations set out above.

2

AGENDA

  • Introduction of participating experts
  • Overview of masitinib clinical results
  • Masitinib positioning
  • Q&A

Participants

Asthma Experts

AB Science Management and Scientific

Committee

Pascal CHANEZ, MD, PhD

APHM and Aix Marseille University

at Marseille France

Lavinia DAVIDESCU, MD, PhD

Faculty of Medicine and Pharmacy,

University of Oradea - Romania.

Elliot ISRAEL, MD

Brigham and Women's Hospital (BWH) - Boston - USA

Alain MOUSSY, MBA

Co-founder and Chief Executive Officer.

Laurent GUY, MBA

Chief Financial Officer

Oliver HERMINE, MD, PhD

Chief Scientific Officer and Caiman of Scientific Committee

4

Masitinib profile

Masitinib is a selective kinase inhibitor that targets mast cells and macrophages/microglia. It is orally administered.

  • Masitinib targets mast cells
    • Masitinib is a potent and selective inhibitor of mast cells, through the inhibition ofc-Kit, Lyn and Fyn kinases.
  • Masitinib targets macrophages/microglia
    • Masitinib is a potent and selective inhibitor of Macrophage Colony Stimulating Factor Receptor 1(MCSFR-1)
  • Masitinib is highly selective
    • Masitinib does not inhibit ABL, Flt3, SRC, and VEGFR
    • Masitinib high kinase selectivity limits the risk ofoff-target toxicity1,2such as cardiac toxicity or opportunistic infections
  • Masitinib is orally administered
    • Tablet in 2 dosage forms
    • Morning and evening intake

Kinase inhibition profile of masitinib

Cellular Target

Molecular Target

IC50[nM]

Kd [µM]

KIT wild-type (WT)

200

0.008

Mast cells

FYN

240

0.14

LYN

225

0.061

Microglia

MCSFR-1

90

0.0076

Masitinib

Notes

  • Dubreuil 2009, PLoSONE.4(9):e7258; AB Science

2 Davis 2011, Nat Biotechnol; 29(11):1046

5

Scientific Rationale

Masitinib is a first in class drug in asthma, selectively targeting mast cells.

  • Mast cells are involved in allergic and anaphylactic reactions.
  • Mast cells are involved in inflammatory diseases [1].
    • Mast cells are activated by triggers leading to selective release ofpro-inflammatory mediators
  • Mast cells play an important role not only in immediate hypersensitivity and late phase inflammation but also in tissue remodeling of the airways [2].
    • Mediators such as tryptase and cytokines from MCs can modulate Airway Smooth Muscle (ASM) cell function.
    • Infiltration of ASM by mast cells (MCs) is associated with the disordered airway function.
    • Increase in Airway Smooth Muscle (ASM) mass is recognized as one of the most important factors related to AHR and to the severity of asthma.
    • Persistent airwayhyper-responsiveness (AHR) is associated with airway remodeling.
    • MCs were found to contribute to the development of multiple features of chronic asthma inMC-deficient mice.
  • Mast cells play a key role in the development of late airwayhyper-responsiveness (AHR) also through liberation of TNF-alpha [3].
  1. Theoharides TC et al. The critical role of mast cells in allergy and inflammation. Ann N Y Acad Sci. 20061088:78-99.
  2. Okayama Y et al. Role of mast cells in airway remodeling. Curr Opin Immunol. 200719(6):687-93

[3] Kim YS et al. Eur J Immunol. 2007 37(4):1107-15

6

Scientific Rationale

Masitinib activity has been established in asthma mouse model.

Effect of masitinib on the bronchoconstriction

Effect of masitinib on the number inflammatory cells

measured by Penh in AHR

measured by eosinophils in BAL of mice

Masitinib induces in asthma mouse model a

Masitinib induces in asthma mouse model a

significant decrease of airway hyper-responsiveness

significant decrease of eosinophils recruitment

Effect of treatment with AB1010 at 25mg/Kg by gavage 1 time per day for a period of 5 days on ovalbumin-sensitized mice (n=11)

The sensitisation of mice with ovalbumin (50µg) by intraperitonal injection on days 1 and 7 followed by intranasal challenges with ovalbumin (10µg) every day from days 18 to 21 induced the 2 major components of the asthmatic airways an allergic inflammation with recruitment of eosinophils and the airway hyperresponsiveness. To reduce the asthma symptoms, the AB1010 treatment started on days 17 to 21.On day 22, airway hyperresponsiveness (AHR) was measured by the enhanced pause (Penh) in the whole body plethysmograph, which is a widely used measurement for AHR. The bronchoconstrictive response was evaluated as the response to a concentration-dependent methacholine aerosol exposure. The infiltration of inflammatory cells has been assessed by histological determination in the bronchoalveolar

lavage fluid (BAL).

7

Clinical Development

The development program in asthma is comprised of one proof of concept study, one positive phase 3 study is severe asthma uncontrolled by oral corticosteroids (OCS), and one on-going phase 3 study is severe asthma uncontrolled by inhaled corticosteroids (ICS).

Phase

Study code

Design

Population

Primary

Patient

IDMC

Study

Related

endpoint

target

recommendation

status

publications

AB04026

Double-blind,

Patients with severe

Change from baseline

Humbert M,

in corticosteroids

Study

2a

(NCT0084

placebo-controlled,

corticosteroid dependent

44

NA

Chanez P,

doses, after

completed

2270)

parallel-group study

asthma

2009

4 months of treatment

Severe Asthma

Continuation of the

AB07015

Prospective, double-

Patients with severe

exacerbation rate

study without

blind, placebo-

asthma uncontrolled

adjusted on the

resampling option

Study

3

(NCT0144

420

-

controlled, 2-parallel

with oral

available person-time

(based on interim

completed

9162)

groups study

corticosteroids (OCS)

(time to end of

analysis and safety

treatment)

data)

Patients with severe

Severe Asthma

AB14001

Prospective, double-

asthma uncontrolled with

exacerbation rate

Continuation of the

blind, placebo-

high dose of inhaled

adjusted on the

Recruitment

3

(NCT0377

347

study (based on safety

-

controlled, 2-parallel

corticosteroids (ICS)

available person-time

completed

1040)

data)

groups study

and with elevated

(time to end of

eosinophil levels

treatment)

8

Clinical Development

The proof of concept has been validated through a corticosteroid weaning clinical study in patients with severe asthma uncontrolled with oral corticosteroids.

  • Reduction in asthma exacerbation rate.
    • -38%in the ITT population.
    • -70%in patients with baseline daily prednisone >15 mg.
  • Patients could be weaned from oral corticosteroids (OCS).
    • OCS was decreased between Week 4 and Week 16.
    • 32% treated patients with baseline daily prednisone >15 mg weaned with masitinib, versus 0% in placebo.
  • The overall safety was acceptable.
  • The study achieved its objectives with a limited sample population (n=44), warranting further evaluation of masitinib in asthma.

Allergy. 2009 Aug;64(8):1194-201. Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-

dependent asthmatics. Humbert M, Chanez P.

9

Phase 2/3 study - Design

Study AB07015 evaluated masitinib 6.0 mg/kg/day in patients treated with severe asthma uncontrolled by OCS.

  • Double blind, placebo controlled, randomized 2:1
  • Main Inclusion Criteria
    • Oral corticosteroids (OCS) dose ≥ 7.5 mg daily for at least 3 months prior to screening visit.
    • Patient with history of severe asthma ≥ 1 year.
      • baseline FEV1 ≥35 to <80% of the predicted normal value.
      • at least 2 asthma exacerbations within one year prior to screening visit.
    • Both high (≥ 150K/uL) and low (<150K/uL) eosinophils.
  • Multicenters study
    • EU countries: Czech Republic, France, Germany, Greece, Hungary, Poland, Romania; Slovakia, Spain
    • Non EU countries: Algeria, Argentina, Bulgaria, India, South Africa, Taiwan, Thailand, Tunisia, Ukraine
  • Primary analysis: Study powered to detect 33% reduction on severe asthma exacerbation in severe asthma population (Claim 1)
  • Primary endpoint
    • Number of severe asthma exacerbations divided by the time under treatment for the overall protocol period.
    • 0verall protocol period = main protocol period (from baseline to week 36 time point) + extension period (after the week 36, patients could continue treatment in their original treatment arm without unblinding).
    • Severe asthma exacerbation rate defined as asthma worsening that requires an increase from stable maintenance dose of corticosteroids for at least three days and /or hospitalization because of Asthma.
  • Secondary endpoints:
    • Severe and Moderate asthma exacerbations. Moderate exacerbation defined as asthma deterioration in symptoms, increase in rescue medication use, lasting for 2 or more days and requiring a change in asthma treatment.
    • Quality of life : Asthma Control Questionnaire (ACQ), Use of rescue medication for asthma.

Respiratory functions : Forced Expiratory Volume (FEV1), Forced Vital Capacity (FVC).

10

Phase 2/3 study - Disposition of patients

The Primary analysis was pre-specified in the claim 1 (severe asthma population). A sequential analysis was pre-specified for the claim 2 (severe asthma and high eosinophils). ITT and FAS population were analyzed for sensitivity.

ITT population

N=419All randomized patients (M=279 ; P=140)

Safety Population

N=404

(M=271 ; P=133)

FAS

N=402

(M=269 ; P=133)

Claim 1 population

N=355

(M=240 ; P=115)

Claim 2 population

N=268

(M=181 ; P=87)

Full Analysis Set

Exclusion of 17 patients from ITT population :

  • Patients from sites with critical GCP violations (n = 13)
  • Patients not treated with investigational product (n = 1)
  • Patients with randomization error (randomized twice at two different sites) (n = 1)
  • Patients with no reference Oral Corticosteroid (OCS) dose at screening and baseline (n = 2)

Severe Asthma:

Exclusion of 47 patients from FAS population : - Patients with OCS daily dose ≤ 5.0 mg

Severe Asthma and High eosinophils: Exclusion of 87 patients from claim 1 population : - Patients with eosinophil levels < 0.15 K/uL

Exclusion of 15 patients from ITT population : Patients from sites with critical GCP violations

  • Patients not treated with investigational product
  • Patients with no reference Oral Corticosteroid (OCS) dose at screening and baseline

11

Phase 2/3 study - Efficacy

The pre-specified primary analysis in the severe asthma population (claim 1) demonstrated a statistically significant reduction in severe asthma exacerbations.

AB07015 - Severe Exacerbation Rate - Claim 1 (Severe Asthma)

Average Exposure

Yearly Exacerbation

Estimate

Reduction in

(Months)

Rate

N

adjusted with

Severe

95% CI

p-Value

Masitinib

Placebo

Masitinib

Placebo

covariates

Exacerbation

355

13.7

13.8

0.34

0.48

0.65

35%

(0.47, 0.90)

0.0103

(M=240 ; P=115)

  • Primary analysis is positive and detected a 35% statistically significant difference in severe exacerbation rate between masitinib and placebo.
  • Duration of exposure was well balanced between the treatment arms.

12

Phase 2/3 study - Efficacy

The sensitivity analyses in ITT and FAS populations were also statistically significant, indicating that the results are consistent and robust.

AB07015 - Severe Exacerbation Rate - Sensitivity analyses of population

Average Exposure

Yearly Exacerbation

Estimate

Reduction in

(Months)

Rate

N

adjusted with

Severe

95% CI

p-Value

Masitinib

Placebo

Masitinib

Placebo

covariates

Exacerbation

Full Analysis Set (FAS)

402

13.2

13.1

0.34

0.45

0.67

33%

(0.49, 0.92)

0.0145

(M=269 ; P=133)

Intent To Treat (ITT)

419

13.1

12.8

0.34

0.44

0.67

33%

(0.49, 0.93)

0.0156

(M=181 ; P=87)

  • There was not impact of patient with daily OCS intake <7.5 mg.

13

Phase 2/3 study - Efficacy

There was a center effect, with greater efficacy in the EU countries (-51% reduction in severe asthma exacerbations, p=0.0038).

AB07015 - Severe Exacerbation Rate - Sensitivity analyses in EU countries

Average Exposure

Yearly Exacerbation

Estimate

Reduction in

(Months)

Rate

N

adjusted with

Severe

95% CI

p-Value

Masitinib

Placebo

Masitinib

Placebo

covariates

Exacerbation

Claim 1 (Severe Asthma)

123

13.2

11.4

0.48

0.90

0.49

51%

(0.30, 0.79)

0.0038

(M=83 ; P=40)

Full Analysis Set (FAS)

148

13.0

10.7

0.47

0.81

0.51

49%

(0.32, 0.81)

0.0044

(M=98 ; P=50)

  • In EU countries, the reduction in severe asthma exacerbations was greater than 50% and comparable to the reduction observe with biologic drugs
  • In EU countries, yearly exacerbation rate in the placebo arm was more in line with the expectations (0.90 as compared with 0.48 when considering all countries),
  • Suggesting that Non EU countries enrolled a different and less severe population, with disease controlled by

rigorous follow-up in the context of the clinical trial.

14

Phase 2/3 study - Efficacy

The pre-specified analysis in the severe asthma with high eosinophils (≥150K/uL) population (claim 2) also demonstrated a statistically significant reduction in severe asthma exacerbations.

AB07015 - Severe Exacerbation Rate - Claim 2 (Severe Asthma with high eosinophils ≥ 150K/uL)

Average Exposure

Yearly Exacerbation

Estimate

Reduction in

(Months)

Rate

N

adjusted with

Severe

95% CI

p-Value

Masitinib

Placebo

Masitinib

Placebo

covariates

Exacerbation

268

13.2

13.4

0.34

0.51

0.62

38%

(0.42, 0.91)

0.0156

(M=181 ; P=87)

  • In the claim 2 population, the study detected a 38% statistically significant difference in severe exacerbation rate between masitinib and placebo.
  • Duration of exposure was well balanced between the treatment arms.

15

Phase 2/3 study - Safety

The study demonstrated an acceptable safety profile for the targeted population.

AB07015 - Overall Summary of Adverse Events (AEs) - Safety Population

Masitinib

Placebo

(N = 271)

(N = 133)

n (%)

n (%) m

At least one AE

226 ( 83.4)

109 ( 82.0)

At least one serious AE (non-fatal)*

48 ( 17.7)

22 ( 16.5)

At least one severe AE

130 ( 48.0)

61 ( 45.9)

  • The occurrence of adverse events (AEs) and serious adverse events (SAEs) was comparable between masitinib and placebo.

* Four fatal SAEs were reported(1.1% with masitinib and 0.8% with placebo), all reviewed by the IDMC and non

related to treatment.

16

Phase 2/3 study - Discussion

Study AB07015 demonstrated efficacy in a difficult to treat population, with 100% of patients receiving high dose OCS maintenance therapy and not restricted to high eosinophils.

  • Enrolment of a different population from other asthma trials
  • Oral corticosteroids (OCS) without weaning:oPatient remained on OCS treatment.
    oThis is not a OCS weaning study with decrease of OCS at the start of the study.
  • Eosinophils level

oStudy included both high (≥150K/uL) and low (<150K/uL) eosinophils.

oDefinition of thresholds for high eosinophils (≥150K/uL) is low compared to other studies (≥300K/uL).

Reduction in severe asthma exacerbation rate

-35% overall and -51% in EU countries, without restriction to high eosinophils

Evaluated over a long period of time of around 13.7 months, well balanced between treatment arms.

There was a center effect

In EU countries, comparable efficacy (-51% exacerbations) as other studies with biologics In EU countries, exacerbation rate in placebo arm was in line with the expectations (0.90)

In all countries, exacerbation rate in placebo arm was low (0.48), when considering all countries, suggesting that Non-EU countries enrolled a different and less severe population, with disease controlled by rigorous follow-up in the

context of the clinical trial.

17

Lavinia DAVIDESCU, MD, PhD

  • About Lavinia Davidescu
    • Assistant Professor at the Faculty of Medicine and Pharmacy, University of Oradea.
    • President of Rare Disease Section of Romanian Pneumology Society, member in the boarding Committee of the Romanian Society of Pneumology.
  • Role in masitinib program
    • Coordinating investigator of masitinib study AB07015 in severe asthma uncontrolled with oral corticosteroids.
    • Willing to take an active role in masitinib program in severe asthma.

18

Lavinia Davidescu

Masitinib generated positive results with a favorable safety profile.

  • Masitinib is first in class based on a new mechanism of action
    • First positive large phase 2/3 with a tyrosine kinase inhibitor
    • First positive large phase 2/3 with mast cells as a therapeutic target
  • Efficacy is demonstrated in the general population of asthma population
    • Not restricted to allergic asthma (High IgE)
    • Not restricted to high eosinophils
  • Advantageous mode of administration
    • Orally administered
    • Likely to have better compliance
  • Favorable safety profile
    • No anaphylaxis
    • No opportunistic infection
  • This study warrants confirmatory study

19

Pascal CHANEZ, MD, PhD

About Pascal Chanez

Professor of Respiratory Medicine at the APHM and Aix Marseille University at Marseille France.

Coordinator of a research group at INSERM-CNRS on the role of bronchial epithelium in inflammation and environmental aggression in severe bronchial diseases.

Head of a clinical research group investigating new innovative treatments for severe asthma and COPD.

Author or co-author of more than 300 peer reviewed articles, reviews and monographs.

Editor of the European Respiratory Journal, of the Journal of allergy and clinical Immunology.

Clinical and research interests are devoted to a better understanding of the mechanisms of severe asthma and COPD with a special focus on combining clinical and biological findings to identify new specific biomarkers and therapies.

Role in masitinib program

Lead investigator with M. Humbert of proof of concept study with masitinib (published in Allergy journal).

Investigator in AB07105 study.

Willing to take an active role for future steps of masitinib program in severe asthma.

20

Pascal Chanez

The clinical data are encouraging and we can be optimistic about the future development of masitinib in asthma.

  • The clinical data are supported by a strong and validated mechanism of action
    • Activation of mucosal mast cells releases broncho constrictor mediators and induce airway hyper responsiveness by interaction with smooth muscle.
    • The airway remodeling leads to permanent alterations in the airway architecture.
  • The clinical data are encouraging and one can be optimistic about the future development of masitinib in asthma
    • Significant reduction in asthma exacerbations in difficult to treat severe asthma patients that required oral corticosteroid maintenance treatment.
    • In the EU, the reduction of asthma exacerbation and the placebo effect were comparable to other studies with biologics
    • The reduction of asthma exacerbation was sustained over a long period of time (≥13 months).
    • The safety profile is good based on available data.
  • There is a positive signal and positioning for masitinib in a landscape that as changed dramatically in the past years
    • Masitinib is the first drug targeting mast cells and has a distinctive and relevant mechanism of action.
    • Masitinib can be positioned in patients insufficiently controlled by biologics, in single agent or in combination

21

Elliot ISRAEL, MD

  • About Elliot Israel
    • Director of clinical research in the Pulmonary and Critical Care Medicine Division and an associate physician at Brigham and Women's Hospital (BWH).
    • Professor of medicine at Harvard Medical School.
    • Research interests include therapeutic interventions to alter asthmatic airway hyperactivity and the role of arachidonic acid metabolites in airway narrowing.
    • Author of over 200peer-reviewed publications
    • Currently leads a team researching novel asthma treatments funded by the National Institutes of Health.
    • Recipient of the HMS Daniel D. Federman Outstanding Clinical Educator Award and named one of "Boston's best in Pulmonary Medicine" by Boston Magazine.
  • Role in masitinib program
    • Willing to take an active role in masitinib program in severe asthma.

22

Elliot Israel

The mechanism of action of masitinib is highly relevant for severe asthma and masitinib could potentially address the unmet needs that remains in asthma despite the recent major improvements in this disease.

  • There is still a need for alternative therapies in asthma despite the major progress achieved in the recent years
    • None of the drugs prevented most exacerbations requiring systemic corticosteroids.
    • 33% to 50% of patients are in failure toanti-interleukin therapies.
    • Lack oflong-term safety and effectiveness data at this time.
    • Eosinophils are part of the immune response to parasitic infections. It is unknown if the therapies that decrease eosinophil counts will affect patients' ability to fight such infections.
  • C-KITdependent processes and mast cells contribute to the pathobiologic basis of severe asthma
    • Masitinib proved to blunts airway inflammation and improves associated lung mechanics in a feline model of chronic allergic asthma (Int Arch Allergy Immunol.2012;158(4):369-74).
    • In patients with severe asthma,c-kit inhibition proved to decrease airway hyperresponsiveness, mast-cell counts, and tryptase release (N Engl J Med. 2017 May 18;376(20):1911-1920).
  • Masitinib demonstratedlong-term efficacy in severe asthma uncontrolled by OCS and with Eosinophils ≤300K/uL
  • Masitinib can be position
    • In addition to positioning proposed by Pascal Chanez, or
    • In low eosinophils, defined as <150K/uL or ≤300K/uL, or
    • In the "vulnerable zone" ofanti-interleukin therapies, i.e. severe asthma uncontrolled by high dose inhaled

corticosteroids and with Eosinophils ≥150K/uL and ≤300K/uL.

23

Key differentiating factors

Masitinib has a unique positioning in severe asthma, in terms of administration, mechanism, targeted population, use of OCS and eosinophil count in population studied.

Key Differentiating factors

Administration

Mechanism of action

Severe asthma

%OCS use in trial

phenotype

pop.(note *)

Masitinib

Oral

Mast-cells

All

100%

Omalizumab

Subcutaneous

Anti-IgE

Allergic

0% to 22%

(Xolair, Genentech)

Mepolizumab

(Nucala, GSK)

Subcutaneous

Anti-IL-5

High eosinophils

24% to 31%

FDA

Reslizumab

approved

Intravenous infusion

Anti-IL-5

High eosinophils

17%

(Cinqair, Teva)

therapies

Benralizumab

Subcutaneous

Anti-IL-5R

High eosinophils

-

(Fasenra, AstraZeneca)

Dupilumab

Subcutaneous self-

Anti-IL-4R

High eosinophils

0%

(Dupixent, Sanofi/Regeneron)

administered

Note *: In phase 3 studies excludingthe Oral Corticosteroids (OCS) targeted weaning studies.

Source : For Masitinib, AB Science. For other drugs, ©Institute for Clinical and Economic Review, 2018. Biologic Therapies for Treatment of Asthma Associated with Type 2

24

Inflammation: Effectiveness, Value, and Value-Based Price Benchmarks

Positioning in severe asthma

Masitinib has several strategic positioning opportunities in severe asthma, complementary to biologics strategies.

Options

Masitinib

Eosinophil

Positioning

Count (cells/μL)

In single agent

>300

After biologics

Severe asthma insufficiently

controlled by biologics

in combination with biologics

>300

After biologics

Severe asthma in the

In single agent

≥150 and ≤300

First Line

"Vulnerable" zone of biologics

In single agent

≤300

First Line

Severe asthma not in type 2

inflammatory phenotypes

In single agent

≤150

First Line

25

Intellectual Property

Masitinib IP rights are secured up to 2032 in severe asthma uncontrolled by OCS.

Protection

Item

Duration of protection

Status

Phase 2/3 'Method of

Asthma (severe)

Until 2032

Delivered

use' patents

26

Q&A

27

Disclaimer

AB Science SA published this content on 02 December 2019 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 02 December 2019 20:49:01 UTC

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1st jan.Capitalization (M$)
AB SCIENCE35.32%353
MERCK KGAA-8.08%45 855
KYOWA KIRIN CO., LTD.1.18%11 706
ZHANGZHOU PIENTZEHUANG PHARMACEUTICAL., LTD-0.51%10 851
JAZZ PHARMACEUTICALS PLC-29.52%5 906
BETTA PHARMACEUTICALS CO., LTD.1.95%4 381